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Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 JAMA+Intern+Med 2014 ; 174 (7): 1176-82 Nephropedia Template TP
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DISSEMINATING EVIDENCE FROM A LANDMARK TRIAL: CROSS-SECTIONAL ANALYSIS OF DESCRIPTIONS AND INTERPRETATIONS OF THE ACCORD-LIPID TRIAL IN THE NEWS AND BIOMEDICAL LITERATURE #MMPMID24796406
Downing NS; Cheng T; Krumholz HM; Shah ND; Ross JS
JAMA Intern Med 2014[Jul]; 174 (7): 1176-82 PMID24796406show ga
The lipid component of the Action to Control Cardiovascular Risk in Diabetes trial (ACCORD-Lipid) was a landmark, publicly-funded trial demonstrating that fenofibrate, when added to statin therapy, was not associated with improved cardiovascular outcomes among patients with diabetes. We performed a cross-sectional study of all articles describing results of ACCORD-Lipid in the news and biomedical literature in the 15 months following its publication. For articles published in biomedical journals, we determined whether there was an association between authors? conflict of interests (COI) and trial interpretation. We identified 67 news and 141 biomedical journal articles discussing ACCORD-Lipid. Approximately 30% of news and biomedical journal articles described fenofibrate as ineffective, whereas nearly 20% concluded it was effective. Among articles making a recommendation, approximately 50% of news and 67% of biomedical journal articles supported continued fibrate use. Authors with COI were more likely to describe fenofibrate as effective (27.1% vs. 8.9%; relative risk [RR]=3.03, 95% confidence interval [CI], 1.22?7.50; P=0.008) and to support continued fibrate use (77.4% vs. 45.8%; RR=1.69, 95% CI, 1.07?2.67; P=0.006). ACCORD-Lipid was described inconsistently in news and biomedical journal articles, possibly creating uncertainty among patients and physicians, and COI were associated with more favorable trial interpretation.