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2014 ; 174
(7
): 1176-82
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Descriptions and interpretations of the ACCORD-Lipid trial in the news and
biomedical literature: a cross-sectional analysis
#MMPMID24796406
Downing NS
; Cheng T
; Krumholz HM
; Shah ND
; Ross JS
JAMA Intern Med
2014[Jul]; 174
(7
): 1176-82
PMID24796406
show ga
The lipid component of the Action to Control Cardiovascular Risk in Diabetes
(ACCORD-Lipid) trial was a landmark, publicly funded study demonstrating that
fenofibrate, when added to statin therapy, was not associated with improved
cardiovascular outcomes among patients with diabetes mellitus. We performed a
cross-sectional study of all articles describing the results of ACCORD-Lipid in
the news and biomedical literature in the 15 months following its publication.
For articles published in biomedical journals, we determined whether there was an
association between authors' conflicts of interest and trial interpretation. We
identified 67 news articles and 141 biomedical journal articles discussing
ACCORD-Lipid. Approximately 30% of news and biomedical journal articles described
fenofibrate as ineffective, whereas nearly 20% concluded it was effective. Among
articles making a recommendation, approximately 50% of news and 67% of biomedical
journal articles supported continued fibrate use. Authors with conflicts of
interest were more likely to describe fenofibrate as effective (27.1% vs 8.9%;
relative risk, 3.03; 95% CI, 1.22-7.50; P?=?.008) and support continued fibrate
use (77.4% vs 45.8%; 1.69; 1.07-2.67; P?=?.006). The ACCORD-Lipid trial was
described inconsistently in news and biomedical journal articles, possibly
creating uncertainty among patients and physicians. In addition, conflicts of
interest were associated with more favorable trial interpretation.
|*Conflict of Interest
[MESH]
|*Randomized Controlled Trials as Topic
[MESH]
|Cardiovascular Diseases/*prevention & control
[MESH]
|Cross-Sectional Studies
[MESH]
|Diabetes Complications/*prevention & control
[MESH]
|Evidence-Based Medicine
[MESH]
|Fenofibrate/adverse effects/economics/*therapeutic use
[MESH]
|Humans
[MESH]
|Hypolipidemic Agents/adverse effects/economics/*therapeutic use
[MESH]
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