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10.1007/s13311-014-0282-1 http://scihub22266oqcxt.onion/10.1007/s13311-014-0282-1 C4121451!4121451!24867326     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24867326&cmd=llinks): Failed to open stream: HTTP request failed! 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Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes |pdf=|usr=}}{{24867326}} gab.com Text Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes JO: Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24867326 #FOAvip Major depressive disorder (MDD) is a widespread, severe, debilitating disorder that markedly diminishes quality of life. Medication is commonly effective, but 20?30 % of patients are refractory to medical therapy. The surgical treatment of psychiatric disorders has a negative stigma associated with it owing to historical abuses. Various ablative surgeries for MDD have been attempted with marginal success, but these studies lacked standardized outcome measures. The recent development of neuromodulation therapy, especially deep brain stimulation (DBS), has enabled controlled studies with sham stimulation and presents a potential therapeutic option that is both reversible and adjustable. We performed a systematic review of the literature pertaining to DBS for treatment-resistant depression to evaluate the safety and efficacy of this procedure. We included only studies using validated outcome measures. Our review identified 22 clinical research papers with 5 unique DBS approaches using different targets, including nucleus accumbens, ventral striatum/ventral capsule, subgenual cingulate cortex, lateral habenula, inferior thalamic nucleus, and medial forebrain bundle. Among the 22 published studies, only 3 were controlled trials, and 2, as yet unpublished, multicenter, randomized, controlled trials evaluating the efficacy of subgenual cingulate cortex and ventral striatum/ventral capsule DBS were recently discontinued owing to inefficacy based on futility analyses. Overall, the published response rate to DBS therapy, defined as the percentage of patients with?>?50 % improvement on the Hamilton Depression Rating Scale, is reported to be 40?70 %, and outcomes were comparable across studies. We conclude that DBS for MDD shows promise, but remains experimental and further accumulation of data is warranted.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-014-0282-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes ????Neurotherapeutics http://www.kidney.de/pget.php?&tw=1&pmid=24867326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24867326 #FOAvip English Wikipedia <ref>{{Cite pmid|24867326}}</ref> Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes #MMPMID24867326 Morishita T; Fayad SM; Higuchi Ma; Nestor KA; Foote KD Neurotherapeutics 2014[Jul]; 11 (3): 475-84 PMID24867326show ga Major depressive disorder (MDD) is a widespread, severe, debilitating disorder that markedly diminishes quality of life. Medication is commonly effective, but 20?30 % of patients are refractory to medical therapy. The surgical treatment of psychiatric disorders has a negative stigma associated with it owing to historical abuses. Various ablative surgeries for MDD have been attempted with marginal success, but these studies lacked standardized outcome measures. The recent development of neuromodulation therapy, especially deep brain stimulation (DBS), has enabled controlled studies with sham stimulation and presents a potential therapeutic option that is both reversible and adjustable. We performed a systematic review of the literature pertaining to DBS for treatment-resistant depression to evaluate the safety and efficacy of this procedure. We included only studies using validated outcome measures. Our review identified 22 clinical research papers with 5 unique DBS approaches using different targets, including nucleus accumbens, ventral striatum/ventral capsule, subgenual cingulate cortex, lateral habenula, inferior thalamic nucleus, and medial forebrain bundle. Among the 22 published studies, only 3 were controlled trials, and 2, as yet unpublished, multicenter, randomized, controlled trials evaluating the efficacy of subgenual cingulate cortex and ventral striatum/ventral capsule DBS were recently discontinued owing to inefficacy based on futility analyses. Overall, the published response rate to DBS therapy, defined as the percentage of patients with?>?50 % improvement on the Hamilton Depression Rating Scale, is reported to be 40?70 %, and outcomes were comparable across studies. We conclude that DBS for MDD shows promise, but remains experimental and further accumulation of data is warranted.Electronic supplementary material: The online version of this article (doi:10.1007/s13311-014-0282-1) contains supplementary material, which is available to authorized users. äDeep Brain Stimulation for Treatment-resistant Depression: Systematic (epmc).pdf DeepDyve Pubget Overpricing