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10.4161/epi.27869 http://scihub22266oqcxt.onion/10.4161/epi.27869 C4121358!4121358!24492483     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics 2014 ; 9 (4): 477-82 Nephropedia Template TP {{tp|p=24492483|t=2014. Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers |pdf=|usr=}}{{24492483}} gab.com Text Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=24492483 #FOAvip DNA methylation and polycomb proteins are well-known mediators of epigenetic silencing in mammalian cells. Usually described as mutually exclusive, this statement is today controversial and recent in vitro studies suggest the co-existence of both repressor systems. We addressed this issue in the study of Retinoic Acid Receptor ? (RAR?), a tumor suppressor gene frequently silenced in prostate cancer. We found that the RAR? promoter is hypermethylated in all studied prostate tumors and methylation levels are positively correlated with H3K27me3 enrichments. Thus, by using bisulfite conversion and pyrosequencing of immunoprecipitated H3K27me3 chromatin, we demonstrated that DNA methylation and polycomb repression co-exist in vivo at this locus. We found this repressive association in 6/6 patient tumor samples of different Gleason score, suggesting a strong interplay of DNA methylation and EZH2 to silence RAR? during prostate tumorigenesis. Twit Text FOAVip Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=24492483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24492483 #FOAvip English Wikipedia <ref>{{Cite pmid|24492483}}</ref> Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers #MMPMID24492483 Moison C; Assemat F; Daunay A; Tost J; Guieysse-Peugeot AL; Arimondo PB Epigenetics 2014[Apr]; 9 (4): 477-82 PMID24492483show ga DNA methylation and polycomb proteins are well-known mediators of epigenetic silencing in mammalian cells. Usually described as mutually exclusive, this statement is today controversial and recent in vitro studies suggest the co-existence of both repressor systems. We addressed this issue in the study of Retinoic Acid Receptor ? (RAR?), a tumor suppressor gene frequently silenced in prostate cancer. We found that the RAR? promoter is hypermethylated in all studied prostate tumors and methylation levels are positively correlated with H3K27me3 enrichments. Thus, by using bisulfite conversion and pyrosequencing of immunoprecipitated H3K27me3 chromatin, we demonstrated that DNA methylation and polycomb repression co-exist in vivo at this locus. We found this repressive association in 6/6 patient tumor samples of different Gleason score, suggesting a strong interplay of DNA methylation and EZH2 to silence RAR? during prostate tumorigenesis. äSynergistic chromatin repression of the tumor suppressor gene RARB in (epmc).pdf DeepDyve Pubget Overpricing