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10.1016/j.clim.2014.06.007 http://scihub22266oqcxt.onion/10.1016/j.clim.2014.06.007 C4119527!4119527 !24971701     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24971701 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Immunol 2014 ; 154 (1 ): 49-65 Nephropedia Template TP {{tp|p=24971701 |t=2014. Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin |pdf=|usr=}}{{24971701 }} gab.com Text Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24971701 #FOAvip The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here, we describe a novel mechanism relating to the regulatory role of Neutrophil Gelatinase Associated Lipocalin (NGAL) in modulating the levels of autoantibodies in pristane induced lupus. Following a single injection of pristane intraperitoneally, NGAL expression was induced in both the serum and spleen. Furthermore, NGAL deficient mice were more susceptible to the induction of pristane stimulated autoimmunity, and displayed higher numbers of autoantibody secreting cells and increased expression of activation induced cytidine deaminase (AID) and other inflammatory mediators in the spleen. In contrast, kidney damage was milder in NGAL deficient mice, indicating that NGAL was detrimental in autoantibody mediated kidney disease. These studies indicate that NGAL plays differential roles in different tissues in the context of lupus, and suggest a previously unrecognized role for NGAL in adaptive immunity. Twit Text FOAVip Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24971701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971701 #FOAvip English Wikipedia <ref>{{Cite pmid|24971701 }}</ref> Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin #MMPMID24971701 Pawar RD ; Goilav B ; Xia Y ; Zhuang H ; Herlitz L ; Reeves WH ; Putterman C Clin Immunol 2014[Sep]; 154 (1 ): 49-65 PMID24971701 show ga The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here, we describe a novel mechanism relating to the regulatory role of Neutrophil Gelatinase Associated Lipocalin (NGAL) in modulating the levels of autoantibodies in pristane induced lupus. Following a single injection of pristane intraperitoneally, NGAL expression was induced in both the serum and spleen. Furthermore, NGAL deficient mice were more susceptible to the induction of pristane stimulated autoimmunity, and displayed higher numbers of autoantibody secreting cells and increased expression of activation induced cytidine deaminase (AID) and other inflammatory mediators in the spleen. In contrast, kidney damage was milder in NGAL deficient mice, indicating that NGAL was detrimental in autoantibody mediated kidney disease. These studies indicate that NGAL plays differential roles in different tissues in the context of lupus, and suggest a previously unrecognized role for NGAL in adaptive immunity. |*Terpenes [MESH] |Acute-Phase Proteins/*immunology [MESH] |Animals [MESH] |Autoantibodies/*blood [MESH] |Disease Models, Animal [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Immunohistochemistry [MESH] |Interleukin-12/blood [MESH] |Kidney/pathology [MESH] |Lipocalin-2 [MESH] |Lipocalins/blood/*immunology [MESH] |Lupus Erythematosus, Systemic/*chemically induced [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Polymerase Chain Reaction [MESH] |Proto-Oncogene Proteins/blood/*immunology [MESH]Serum autoantibodies in pristane induced lupus are regulated by neutro(epmc).pdf DeepDyve Pubget Overpricing