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10.1111/joim.12247 http://scihub22266oqcxt.onion/10.1111/joim.12247 C4119467!4119467!24697828     free     free     free       J+Intern+Med 2014 ; 276 (1): 12-24 Nephropedia Template TP {{tp|p=24697828|t=2014. Metabolic regulation of stem cell function |pdf=|usr=}}{{24697828}} gab.com Text Metabolic regulation of stem cell function JO: J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=24697828 #FOAvip Stem cell function is regulated by intrinsic mechanisms, such as transcriptional and epigenetic regulators, as well as extrinsic mechanisms, such as short-range signals from the niche and long-range humoral signals. Interactions between these regulatory mechanisms and cellular metabolism are just beginning to be identified. In multiple systems, differentiation is accompanied by changes in glycolysis, oxidative phosphorylation, and the levels of reactive oxygen species. Indeed, metabolic pathways regulate proliferation and differentiation by regulating energy production and the generation of substrates for biosynthetic pathways. Some metabolic pathways appear to function differently in stem cells as compared with restricted progenitors and differentiated cells. They also appear to influence stem cell function by regulating signal transduction, epigenetic marks, and oxidative stress. Studies to date illustrate the importance of metabolism in the regulation of stem cell function and suggest complex cross regulation likely exists between metabolism and other stem cell regulatory mechanisms. Twit Text FOAVip Metabolic regulation of stem cell function ????J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=24697828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24697828 #FOAvip English Wikipedia <ref>{{Cite pmid|24697828}}</ref> Metabolic regulation of stem cell function #MMPMID24697828 Burgess RJ; Agathocleous M; Morrison SJ J Intern Med 2014[Jul]; 276 (1): 12-24 PMID24697828show ga Stem cell function is regulated by intrinsic mechanisms, such as transcriptional and epigenetic regulators, as well as extrinsic mechanisms, such as short-range signals from the niche and long-range humoral signals. Interactions between these regulatory mechanisms and cellular metabolism are just beginning to be identified. In multiple systems, differentiation is accompanied by changes in glycolysis, oxidative phosphorylation, and the levels of reactive oxygen species. Indeed, metabolic pathways regulate proliferation and differentiation by regulating energy production and the generation of substrates for biosynthetic pathways. Some metabolic pathways appear to function differently in stem cells as compared with restricted progenitors and differentiated cells. They also appear to influence stem cell function by regulating signal transduction, epigenetic marks, and oxidative stress. Studies to date illustrate the importance of metabolism in the regulation of stem cell function and suggest complex cross regulation likely exists between metabolism and other stem cell regulatory mechanisms. äMetabolic regulation of stem cell function (epmc).pdf DeepDyve Pubget Overpricing