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10.1016/j.bpj.2014.05.028 http://scihub22266oqcxt.onion/10.1016/j.bpj.2014.05.028 C4119274!4119274!24988345     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24988345&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2014 ; 107 (1): 100-13 Nephropedia Template TP {{tp|p=24988345|t=2014. The Extracellular ?-Domain is Essential for the Formation of CD81 Tetraspanin Webs |pdf=|usr=}}{{24988345}} gab.com Text The Extracellular -Domain is Essential for the Formation of CD81 Tetraspanin Webs JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=24988345 #FOAvip CD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular ?-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The ?-domain is also essential for the platforms to function during viral entry. We propose that, instead of stable binary interactions, CD81 interactions via the small ?-domain, possibly involving a dimerization step, play the key role in organizing CD81 into large tetraspanin webs and controlling its function. Twit Text FOAVip The Extracellular -Domain is Essential for the Formation of CD81 Tetraspanin Webs ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=24988345 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24988345 #FOAvip English Wikipedia <ref>{{Cite pmid|24988345}}</ref> The Extracellular ?-Domain is Essential for the Formation of CD81 Tetraspanin Webs #MMPMID24988345 Homsi Y; Schloetel JG; Scheffer K; Schmidt T; Destainville N; Florin L; Lang T Biophys J 2014[Jul]; 107 (1): 100-13 PMID24988345show ga CD81 is a ubiquitously expressed member of the tetraspanin family. It forms large molecular platforms, so-called tetraspanin webs that play physiological roles in a variety of cellular functions and are involved in viral and parasite infections. We have investigated which part of the CD81 molecule is required for the formation of domains in the cell membranes of T-cells and hepatocytes. Surprisingly, we find that large CD81 platforms assemble via the short extracellular ?-domain, independent from a strong primary partner binding and from weak interactions mediated by palmitoylation. The ?-domain is also essential for the platforms to function during viral entry. We propose that, instead of stable binary interactions, CD81 interactions via the small ?-domain, possibly involving a dimerization step, play the key role in organizing CD81 into large tetraspanin webs and controlling its function. äThe Extracellular ?-Domain is Essential for the Formation of CD81 Tetr(epmc).pdf DeepDyve Pubget Overpricing