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10.1016/j.coi.2014.03.004

http://scihub22266oqcxt.onion/10.1016/j.coi.2014.03.004
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C4118594!4118594!24762410
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suck abstract from ncbi

pmid24762410      Curr+Opin+Immunol 2014 ; 28 (ä): 102-6
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  • Interleukin 33: A Switch-Hitting Cytokine #MMPMID24762410
  • Villarreal DO; Weiner DB
  • Curr Opin Immunol 2014[Jun]; 28 (ä): 102-6 PMID24762410show ga
  • For many years IL-33 has been widely studied in the context of T helper type 2 (TH2)-driven inflammatory disorders. Interestingly, IL-33 has now emerged as a cytokine with a plethora of pleiotropic properties. Depending on the immune cells targeted by IL-33, it is reported to not only promote TH2 immunity, but also to induce T helper type 1 (TH1) immunity. Furthermore, recent studies have revealed that IL-33 can activate CD8+ T cells. These new studies provide evidence for its beneficial role in antiviral and antitumor immunity. Here we review the evidence of IL-33 to drive protective T cell immunity plus its potential use as an adjuvant in vaccination and tumor therapy.
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