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10.1093/glycob/cwu068 http://scihub22266oqcxt.onion/10.1093/glycob/cwu068 C4116048!4116048!24996822     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Glycobiology 2014 ; 24 (9): 800-6 Nephropedia Template TP {{tp|p=24996822|t=2014. Siglec-G/10 in self?nonself discrimination of innate and adaptive immunity |pdf=|usr=}}{{24996822}} gab.com Text Siglec-G/10 in self nonself discrimination of innate and adaptive immunity JO: Glycobiology http://www.kidney.de/pget.php?&tw=1&pmid=24996822 #FOAvip Siglec-G/10 is broadly expressed on B cells, dendritic cells and macrophage subsets. It binds strongly to CD24, a small glycosyl-phosphatidylinositol-anchored sialoprotein, in a sialylation-dependent manner. Targeted mutation of Siglecg dramatically elevates the level of natural IgM antibodies and its producer, B1 B cells. Incorporation of Siglec-G ligands to both T-dependent and T-independent immunogens reduces antibody production and induces B-cell tolerance to subsequent antigen challenges. By interacting with CD24, Siglec-G suppresses inflammatory responses to danger (damage)-associated molecular patterns, such as heat-shock proteins and high mobility group protein 1, but not to Toll-like receptor ligands. By a CD24-independent mechanism, Siglec-G has been shown to associate with Cbl to cause degradation of retinoic acid-inducible gene 1 and reduce production of type I interferon in response to RNA virus infection. The negative regulation by Siglec-G/10 may provide a mechanism for the host to discriminate between infectious nonself and noninfectious self, as envisioned by the late Dr. Charles A. Janeway. Twit Text FOAVip Siglec-G/10 in self nonself discrimination of innate and adaptive immunity ????Glycobiology http://www.kidney.de/pget.php?&tw=1&pmid=24996822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24996822 #FOAvip English Wikipedia <ref>{{Cite pmid|24996822}}</ref> Siglec-G/10 in self?nonself discrimination of innate and adaptive immunity #MMPMID24996822 Chen GY; Brown NK; Zheng P; Liu Y Glycobiology 2014[Sep]; 24 (9): 800-6 PMID24996822show ga Siglec-G/10 is broadly expressed on B cells, dendritic cells and macrophage subsets. It binds strongly to CD24, a small glycosyl-phosphatidylinositol-anchored sialoprotein, in a sialylation-dependent manner. Targeted mutation of Siglecg dramatically elevates the level of natural IgM antibodies and its producer, B1 B cells. Incorporation of Siglec-G ligands to both T-dependent and T-independent immunogens reduces antibody production and induces B-cell tolerance to subsequent antigen challenges. By interacting with CD24, Siglec-G suppresses inflammatory responses to danger (damage)-associated molecular patterns, such as heat-shock proteins and high mobility group protein 1, but not to Toll-like receptor ligands. By a CD24-independent mechanism, Siglec-G has been shown to associate with Cbl to cause degradation of retinoic acid-inducible gene 1 and reduce production of type I interferon in response to RNA virus infection. The negative regulation by Siglec-G/10 may provide a mechanism for the host to discriminate between infectious nonself and noninfectious self, as envisioned by the late Dr. Charles A. Janeway. äSiglec-G/10 in self?nonself discrimination of innate and adaptive immu(epmc).pdf DeepDyve Pubget Overpricing