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10.1073/pnas.1404271111 http://scihub22266oqcxt.onion/10.1073/pnas.1404271111 C4115544!4115544!24994901     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24994901&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (29): 10666-71 Nephropedia Template TP {{tp|p=24994901|t=2014. 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling |pdf=|usr=}}{{24994901}} gab.com Text 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24994901 #FOAvip The lipid 25-hydroxycholesterol (25HC) is produced by immune cells in response to infection. We demonstrate that in addition to interfering with viral entry and replication, 25HC also amplifies the activation of immune cells and increases the production of immune mediators. Furthermore, we show that the presence of 25HC is actually harmful in the setting of infection with influenza because the production of these immune mediators leads to damage to the host. These observations might have particular relevance for understanding the mechanisms behind the high pathogenicity of several recently emerged influenza strains, including the H5N1 ?bird flu,? and might have implications for the protection of the host from these virulent strains. Twit Text FOAVip 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=24994901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24994901 #FOAvip English Wikipedia <ref>{{Cite pmid|24994901}}</ref> 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling #MMPMID24994901 Gold ES; Diercks AH; Podolsky I; Podyminogin RL; Askovich PS; Treuting PM; Aderem A Proc Natl Acad Sci U S A 2014[Jul]; 111 (29): 10666-71 PMID24994901show ga The lipid 25-hydroxycholesterol (25HC) is produced by immune cells in response to infection. We demonstrate that in addition to interfering with viral entry and replication, 25HC also amplifies the activation of immune cells and increases the production of immune mediators. Furthermore, we show that the presence of 25HC is actually harmful in the setting of infection with influenza because the production of these immune mediators leads to damage to the host. These observations might have particular relevance for understanding the mechanisms behind the high pathogenicity of several recently emerged influenza strains, including the H5N1 ?bird flu,? and might have implications for the protection of the host from these virulent strains. ä25-Hydroxycholesterol acts as an amplifier of inflammatory signaling (epmc).pdf DeepDyve Pubget Overpricing