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Use of Magnetic Resonance Imaging to Monitor Iron Overload #MMPMID25064711
Wood JC
Hematol Oncol Clin North Am 2014[Aug]; 28 (4): 747-64 PMID25064711show ga
Treatment of iron overload requires robust estimates of total body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject variability in chelator effectiveness is extremely high, necessitating reliable iron estimates to guide dose titration. In addition, each chelator has a unique profile with respect to clearing iron stores from different organs. This chapter will present the tools available to clinicians monitoring their patients, focusing on non-invasive magnetic resonance imaging methods because they have become the de-facto standard of care.