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10.4161/sgtp.29769 http://scihub22266oqcxt.onion/10.4161/sgtp.29769 C4114922!4114922!24987837     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2014 ; 5 (ä): ä Nephropedia Template TP {{tp|p=24987837|t=2014. Function and regulation of the Rho guanine nucleotide exchange factor Trio |pdf=|usr=}}{{24987837}} gab.com Text Function and regulation of the Rho guanine nucleotide exchange factor Trio JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=24987837 #FOAvip Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which accelerate the GDP to GTP exchange. RhoGEFs fall into two different classes: the Dbl family and the DOCK family of proteins. In this review, we focus on the function and regulation of the Dbl family RhoGEF Trio. Trio and its paralog Kalirin are unique within this family in that they display two GEF domains of distinct specificity. Trio is a major regulator of neuronal development, and its function is conserved through evolution. Moreover, Trio plays an important role in cell adhesion and in signaling pathways elicited by G?q protein-coupled receptors. Combined, these observations suggest that Trio has a major role in cellular physiology. Of note, Trio is an essential gene for mouse development, with a prominent role in the development of the nervous system. Finally, Trio expression is significantly increased in different types of tumors and it has been proposed that it could participate in oncogenesis. Twit Text FOAVip Function and regulation of the Rho guanine nucleotide exchange factor Trio ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=24987837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24987837 #FOAvip English Wikipedia <ref>{{Cite pmid|24987837}}</ref> Function and regulation of the Rho guanine nucleotide exchange factor Trio #MMPMID24987837 Schmidt S; Debant A Small GTPases 2014[]; 5 (ä): ä PMID24987837show ga Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which accelerate the GDP to GTP exchange. RhoGEFs fall into two different classes: the Dbl family and the DOCK family of proteins. In this review, we focus on the function and regulation of the Dbl family RhoGEF Trio. Trio and its paralog Kalirin are unique within this family in that they display two GEF domains of distinct specificity. Trio is a major regulator of neuronal development, and its function is conserved through evolution. Moreover, Trio plays an important role in cell adhesion and in signaling pathways elicited by G?q protein-coupled receptors. Combined, these observations suggest that Trio has a major role in cellular physiology. Of note, Trio is an essential gene for mouse development, with a prominent role in the development of the nervous system. Finally, Trio expression is significantly increased in different types of tumors and it has been proposed that it could participate in oncogenesis. äFunction and regulation of the Rho guanine nucleotide exchange factor (epmc).pdf DeepDyve Pubget Overpricing