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10.4049/jimmunol.1400321 http://scihub22266oqcxt.onion/10.4049/jimmunol.1400321 C4114159!4114159!24890722     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (1): 21-5 Nephropedia Template TP {{tp|p=24890722|t=2014. Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation |pdf=|usr=}}{{24890722}} gab.com Text Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24890722 #FOAvip Thymic dendritic cells (DC) mediate self-tolerance by presenting self-peptides to and depleting autoreactive thymocytes. Despite a significant role in negative selection, the events regulating thymic DC maturation and function under steady-state conditions are poorly understood. We report that crosstalk with thymocytes regulates thymic conventional DC (cDC) numbers, phenotype, and function. In mice lacking TCR-expressing thymocytes, thymic cDC were reduced and exhibited a less mature phenotype. Furthermore, thymic cDC in TCR transgenic mice lacking cognate antigen expression in the thymus were also immature; notably, however, thymic cDC maturation was reestablished by an Ag-specific cognate interaction with CD4+ or CD8+ single-positive thymocytes (SP). Blockade of CD40 ligand during Ag-specific interactions with CD4SP but not CD8SP limited the effect on cDC maturation. Together, these novel findings demonstrate that homeostatic maturation and function of thymic cDC is regulated by feedback delivered by CD4SP and CD8SP via distinct mechanisms during a cognate Ag-specific interaction. Twit Text FOAVip Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24890722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24890722 #FOAvip English Wikipedia <ref>{{Cite pmid|24890722}}</ref> Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation #MMPMID24890722 Spidale NA; Wang B; Tisch R J Immunol 2014[Jul]; 193 (1): 21-5 PMID24890722show ga Thymic dendritic cells (DC) mediate self-tolerance by presenting self-peptides to and depleting autoreactive thymocytes. Despite a significant role in negative selection, the events regulating thymic DC maturation and function under steady-state conditions are poorly understood. We report that crosstalk with thymocytes regulates thymic conventional DC (cDC) numbers, phenotype, and function. In mice lacking TCR-expressing thymocytes, thymic cDC were reduced and exhibited a less mature phenotype. Furthermore, thymic cDC in TCR transgenic mice lacking cognate antigen expression in the thymus were also immature; notably, however, thymic cDC maturation was reestablished by an Ag-specific cognate interaction with CD4+ or CD8+ single-positive thymocytes (SP). Blockade of CD40 ligand during Ag-specific interactions with CD4SP but not CD8SP limited the effect on cDC maturation. Together, these novel findings demonstrate that homeostatic maturation and function of thymic cDC is regulated by feedback delivered by CD4SP and CD8SP via distinct mechanisms during a cognate Ag-specific interaction. äAntigen-specific thymocyte feedback regulates homeostatic thymic conve(epmc).pdf DeepDyve Pubget Overpricing