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10.1016/j.chom.2014.05.015 http://scihub22266oqcxt.onion/10.1016/j.chom.2014.05.015 C4113907!4113907!24922570     free     free     free       Cell+Host+Microbe 2014 ; 15 (6): 668-80 Nephropedia Template TP {{tp|p=24922570|t=2014. Advances in Norovirus Biology |pdf=|usr=}}{{24922570}} gab.com Text Advances in Norovirus Biology JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=24922570 #FOAvip Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide, and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a particularly challenging pathogen to study, recent advances in norovirus animal models and in vitro cultivation systems have led to an increased understanding of norovirus molecular biology and replication, pathogenesis, cell tropism, and innate and adaptive immunity. Furthermore, clinical trials of vaccines consisting of nonreplicating virus-like particles have shown promise. In this review, we summarize these recent advances and discuss controversies in the field, which is rapidly progressing towards generation of antiviral agents and increasingly effective vaccines. Twit Text FOAVip Advances in Norovirus Biology ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=24922570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24922570 #FOAvip English Wikipedia <ref>{{Cite pmid|24922570}}</ref> Advances in Norovirus Biology #MMPMID24922570 Karst SM; Wobus CE; Goodfellow IG; Green KY; Virgin HW Cell Host Microbe 2014[Jun]; 15 (6): 668-80 PMID24922570show ga Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide, and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a particularly challenging pathogen to study, recent advances in norovirus animal models and in vitro cultivation systems have led to an increased understanding of norovirus molecular biology and replication, pathogenesis, cell tropism, and innate and adaptive immunity. Furthermore, clinical trials of vaccines consisting of nonreplicating virus-like particles have shown promise. In this review, we summarize these recent advances and discuss controversies in the field, which is rapidly progressing towards generation of antiviral agents and increasingly effective vaccines. äAdvances in Norovirus Biology (epmc).pdf DeepDyve Pubget Overpricing