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10.1016/j.cell.2014.04.033 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.04.033 C4113015!4113015!24949972     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 157 (7): 1605-18 Nephropedia Template TP {{tp|p=24949972|t=2014. Programmed Translational Readthrough Generates Anti-Angiogenic VEGF-Ax |pdf=|usr=}}{{24949972}} gab.com Text Programmed Translational Readthrough Generates Anti-Angiogenic VEGF-Ax JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24949972 #FOAvip Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here we show that vascular endothelial growth factor-A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino acid C-terminus extension. A cis-acting element in the VEGFA 3?UTR serves a dual function, not only encoding the appended peptide, but also directing the PTR by decoding the UGA stop codon as serine. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 binds this element and promotes readthrough. Remarkably, VEGF-Ax exhibits anti-angiogenic activity in contrast to the pro-angiogenic activity of VEGF-A. Pathophysiological significance of VEGF-Ax is indicated by robust expression in multiple human tissues, but depletion in colon adenocarcinoma. Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. Twit Text FOAVip Programmed Translational Readthrough Generates Anti-Angiogenic VEGF-Ax ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24949972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24949972 #FOAvip English Wikipedia <ref>{{Cite pmid|24949972}}</ref> Programmed Translational Readthrough Generates Anti-Angiogenic VEGF-Ax #MMPMID24949972 Eswarappa SM; Potdar AA; Koch WJ; Fan Y; Vasu K; Lindner D; Willard B; Graham LM; DiCorleto PE; Fox PL Cell 2014[Jun]; 157 (7): 1605-18 PMID24949972show ga Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here we show that vascular endothelial growth factor-A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino acid C-terminus extension. A cis-acting element in the VEGFA 3?UTR serves a dual function, not only encoding the appended peptide, but also directing the PTR by decoding the UGA stop codon as serine. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 binds this element and promotes readthrough. Remarkably, VEGF-Ax exhibits anti-angiogenic activity in contrast to the pro-angiogenic activity of VEGF-A. Pathophysiological significance of VEGF-Ax is indicated by robust expression in multiple human tissues, but depletion in colon adenocarcinoma. Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. äProgrammed Translational Readthrough Generates Anti-Angiogenic VEGF-Ax(epmc).pdf DeepDyve Pubget Overpricing