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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Res 2014 ; 74 (11): 2922-7 Nephropedia Template TP
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Cancer Stem Cells: Constantly Evolving and Functionally Heterogeneous Therapeutic Targets #MMPMID24713433
Yang T; Rycaj K; Liu ZM; Tang DG
Cancer Res 2014[Jun]; 74 (11): 2922-7 PMID24713433show ga
Elucidating the origin of and dynamic interrelationship between intratumoral cell subpopulations has clear clinical significance in helping understand the cellular basis of treatment response, therapeutic resistance, and tumor relapse. Cancer stem cells (CSC), together with clonal evolution driven by genetic alterations, generate cancer cell heterogeneity commonly observed in clinical samples. The 2013 Shanghai International Symposium on Cancer Stem Cells# brought together leaders in the field to highlight the most recent progress in phenotyping, characterizing, and targeting CSC and in elucidating the relationship between the cell-of-origin of cancer versus CSC. Discussions from the symposium emphasize the urgent need in developing novel therapeutics to target the constantly evolving CSC.