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10.1016/S1474-4422(14)70065-1 http://scihub22266oqcxt.onion/10.1016/S1474-4422(14)70065-1 C4112126!4112126!24943344     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Neurol 2014 ; 13 (7): 686-99 Nephropedia Template TP {{tp|p=24943344|t=2014. Frontotemporal dementia and its subtypes: a genome-wide association study |pdf=|usr=}}{{24943344}} gab.com Text Frontotemporal dementia and its subtypes: a genome-wide association study JO: Lancet Neurol http://www.kidney.de/pget.php?&tw=1&pmid=24943344 #FOAvip Background: Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes?MAPT, GRN, and C9orf72?have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. Methods: We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. All participants had European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10?8) and suggestive single-nucleotide polymorphisms. Findings: We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10?8) that encompassed the HLA locus at 6p21.3 in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC, for the behavioural FTD subtype. Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation incis. Interpretation: Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and possibly to shed light on the pathomechanisms contributing to FTD. Funding: The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/ MRC Centre on Parkinson?s disease, Alzheimer?s Research UK, and Texas Tech University Health Sciences Center. Twit Text FOAVip Frontotemporal dementia and its subtypes: a genome-wide association study ????Lancet Neurol http://www.kidney.de/pget.php?&tw=1&pmid=24943344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24943344 #FOAvip English Wikipedia <ref>{{Cite pmid|24943344}}</ref> Frontotemporal dementia and its subtypes: a genome-wide association study #MMPMID24943344 Ferrari R; Hernandez DG; Nalls MA; Rohrer JD; Ramasamy A; Kwok JBJ; Dobson-Stone C; Brooks WS; Schofield PR; Halliday GM; Hodges JR; Piguet O; Bartley L; Thompson E; Haan E; Hernández I; Ruiz A; Boada M; Borroni B; Padovani A; Cruchaga C; Cairns NJ; Benussi L; Binetti G; Ghidoni R; Forloni G; Galimberti D; Fenoglio C; Serpente M; Scarpini E; Clarimón J; Lleó A; Blesa R; Waldö ML; Nilsson K; Nilsson C; Mackenzie IRA; Hsiung GYR; Mann DMA; Grafman J; Morris CM; Attems J; Griffiths TD; McKeith IG; Thomas AJ; Pietrini P; Huey ED; Wassermann EM; Baborie A; Jaros E; Tierney MC; Pastor P; Razquin C; Ortega-Cubero S; Alonso E; Perneczky R; Diehl-Schmid J; Alexopoulos P; Kurz A; Rainero I; Rubino E; Pinessi L; Rogaeva E; George-Hyslop PS; Rossi G; Tagliavini F; Giaccone G; Rowe JB; Schlachetzki JCM; Uphill J; Collinge J; Mead S; Danek A; Van Deerlin VM; Grossman M; Trojanowsk JQ; van der Zee J; Deschamps W; Van Langenhove T; Cruts M; Van Broeckhoven C; Cappa SF; Le Ber I; Hannequin D; Golfier V; Vercelletto M; Brice A; Nacmias B; Sorbi S; Bagnoli S; Piaceri I; Nielsen JE; Hjermind LE; Riemenschneider M; Mayhaus M; Ibach B; Gasparoni G; Pichler S; Gu W; Rossor MN; Fox NC; Warren JD; Spillantini MG; Morris HR; Rizzu P; Heutink P; Snowden JS; Rollinson S; Richardson A; Gerhard A; Bruni AC; Maletta R; Frangipane F; Cupidi C; Bernardi L; Anfossi M; Gallo M; Conidi ME; Smirne N; Rademakers R; Baker M; Dickson DW; Graff-Radford NR; Petersen RC; Knopman D; Josephs KA; Boeve BF; Parisi JE; Seeley WW; Miller BL; Karydas AM; Rosen H; van Swieten JC; Dopper EGP; Seelaar H; Pijnenburg YA; Scheltens P; Logroscino G; Capozzo R; Novelli V; Puca AA; Franceschi M; Postiglione A; Milan G; Sorrentino P; Kristiansen M; Chiang HH; Graff C; Pasquier F; Rollin A; Deramecourt V; Lebert F; Kapogiannis D; Ferrucci L; Pickering-Brown S; Singleton AB; Hardy J; Momeni P Lancet Neurol 2014[Jul]; 13 (7): 686-99 PMID24943344show ga Background: Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes?MAPT, GRN, and C9orf72?have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. Methods: We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. All participants had European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10?8) and suggestive single-nucleotide polymorphisms. Findings: We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10?8) that encompassed the HLA locus at 6p21.3 in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC, for the behavioural FTD subtype. Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation incis. Interpretation: Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and possibly to shed light on the pathomechanisms contributing to FTD. Funding: The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/ MRC Centre on Parkinson?s disease, Alzheimer?s Research UK, and Texas Tech University Health Sciences Center. äFrontotemporal dementia and its subtypes: a genome-wide association st(epmc).pdf DeepDyve Pubget Overpricing