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10.1016/j.mvr.2014.04.008 http://scihub22266oqcxt.onion/10.1016/j.mvr.2014.04.008 C4111996!4111996!24788074     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microvasc+Res 2014 ; 94 (ä): 17-27 Nephropedia Template TP {{tp|p=24788074|t=2014. Characterization of nanoparticle delivery in microcirculation using a microfluidic device |pdf=|usr=}}{{24788074}} gab.com Text Characterization of nanoparticle delivery in microcirculation using a microfluidic device JO: Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=24788074 #FOAvip This work focuses on the characterization of particle delivery in microcirculation through a microfluidic device. In microvasculature the vessel size is comparable to that of red blood cells (RBCs) and the existence of blood cells largely influences the dispersion and binding distribution of drug loaded particles. The geometry of the microvasculature leads to non-uniform particle distribution and affects the particle binding characteristics. We perform an in vitro study in a microfluidic chip with micro vessel mimicking channels having a rectangular cross section. Various factors that influence particle distribution and delivery such as the vessel geometry, shear rate, blood cells, particle size, particle antibody density are considered in this study. Around 10% higher particle binding density is observed at bifurcation regions of the mimetic microvasculature geometry compared to straight regions. Particle binding density is found to decrease with increased shear rates. RBCs enhance particle binding for both 210 nm and 2 ?m particles for shear rates between 200-1600 s?1 studied. The particle binding density increases about 2-3 times and 6-10 times when flowing in whole blood at 25% RBC concentration compared to the pure particle case, for 210 nm and 2 ?m particles respectively. With RBCs, the binding enhancement is more significant for 2 ?m particles than that for 210 nm particles, which indicates an enhanced size dependent exclusion of 2 ?m particles from the channel centre to the cell free layer (CFL). Increased particle antibody coating density leads to higher particle binding density for both 210 nm and 2 ?m particles. Twit Text FOAVip Characterization of nanoparticle delivery in microcirculation using a microfluidic device ????Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=24788074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24788074 #FOAvip English Wikipedia <ref>{{Cite pmid|24788074}}</ref> Characterization of nanoparticle delivery in microcirculation using a microfluidic device #MMPMID24788074 Thomas A; Tan J; Liu Y Microvasc Res 2014[Jul]; 94 (ä): 17-27 PMID24788074show ga This work focuses on the characterization of particle delivery in microcirculation through a microfluidic device. In microvasculature the vessel size is comparable to that of red blood cells (RBCs) and the existence of blood cells largely influences the dispersion and binding distribution of drug loaded particles. The geometry of the microvasculature leads to non-uniform particle distribution and affects the particle binding characteristics. We perform an in vitro study in a microfluidic chip with micro vessel mimicking channels having a rectangular cross section. Various factors that influence particle distribution and delivery such as the vessel geometry, shear rate, blood cells, particle size, particle antibody density are considered in this study. Around 10% higher particle binding density is observed at bifurcation regions of the mimetic microvasculature geometry compared to straight regions. Particle binding density is found to decrease with increased shear rates. RBCs enhance particle binding for both 210 nm and 2 ?m particles for shear rates between 200-1600 s?1 studied. The particle binding density increases about 2-3 times and 6-10 times when flowing in whole blood at 25% RBC concentration compared to the pure particle case, for 210 nm and 2 ?m particles respectively. With RBCs, the binding enhancement is more significant for 2 ?m particles than that for 210 nm particles, which indicates an enhanced size dependent exclusion of 2 ?m particles from the channel centre to the cell free layer (CFL). Increased particle antibody coating density leads to higher particle binding density for both 210 nm and 2 ?m particles. äCharacterization of nanoparticle delivery in microcirculation using a (epmc).pdf DeepDyve Pubget Overpricing