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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Cycle 2014 ; 13 (12): 1902-11 Nephropedia Template TP
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NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells #MMPMID24743017
Bellet MM; Piobbico D; Bartoli D; Castelli M; Pieroni S; Brunacci C; Chiacchiaretta M; Del Sordo R; Fallarino F; Sidoni A; Puccetti P; Romani L; Servillo G; Agnese Della Fazia M
Cell Cycle 2014[Jun]; 13 (12): 1902-11 PMID24743017show ga
Liver regeneration is a unique means of studying cell proliferation in vivo. Screening of a large cDNA library from regenerating liver has previously allowed us to identify and characterize a cluster of genes encoding proteins with important roles in proliferative processes. Here, by examining different rat and human tissues as well as cell lines, we characterized a highly conserved gene, guanylyl cyclase domain containing 1 (GUCD1), whose modulation occurs in liver regeneration and cell cycle progression in vitro. High-level expression of GUCD1 transcripts was observed in livers from patients with hepatocellular carcinoma. A yeast two-hybrid interaction assay, aimed at identifying any relevant interaction partners of GUCD1, revealed direct interactions with NEDD4-1 (E3 ubiquitin protein ligase neural precursor cell expressed, developmentally downregulated gene 4), resulting in control of GUCD1 stability. Thus, we have characterized expression and function of a ubiquitous protein, GUCD1, which might have a role in regulating normal and abnormal cell growth in the liver.