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10.4161/cc.28653

http://scihub22266oqcxt.onion/10.4161/cc.28653
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C4111721!4111721!24675887
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suck abstract from ncbi


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pmid24675887      Cell+Cycle 2014 ; 13 (11): 1749-55
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  • Promyelocytic leukemia bodies tether to early endosomes during mitosis #MMPMID24675887
  • Palibrk V; Lång E; Lång A; Schink KO; Rowe AD; Bøe SO
  • Cell Cycle 2014[Jun]; 13 (11): 1749-55 PMID24675887show ga
  • During mitosis the nuclear envelope breaks down, leading to potential interactions between cytoplasmic and nuclear components. PML bodies are nuclear structures with tumor suppressor and antiviral functions. Early endosomes, on the other hand, are cytoplasmic vesicles involved in transport and growth factor signaling. Here we demonstrate that PML bodies form stable interactions with early endosomes immediately following entry into mitosis. The 2 compartments remain stably associated throughout mitosis and dissociate in the cytoplasm of newly divided daughter cells. We also show that a minor subset of PML bodies becomes anchored to the mitotic spindle poles during cell division. The study demonstrates a stable mitosis-specific interaction between a cytoplasmic and a nuclear compartment.
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