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10.4161/cc.29106 http://scihub22266oqcxt.onion/10.4161/cc.29106 C4111701!4111701!24804778     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2014 ; 13 (13): 2101-9 Nephropedia Template TP {{tp|p=24804778|t=2014. The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2 |pdf=|usr=}}{{24804778}} gab.com Text The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2 JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=24804778 #FOAvip The Mdm2 proto-oncoprotein is the primary negative regulator for p53. While it is believed that Mdm2 degradation is regulated via its own E3 ubiquitin ligase activity, recent development of knock-in mouse models demonstrates that Mdm2 E3 ligase function is dispensable for self-degradation in vivo. Here, we show that the anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase for Mdm2 degradation. We demonstrate that APC2, a scaffold subunit of APC/C, binds to Mdm2 and is required for Mdm2 polyubiquitination and proteasomal degradation. Downregulation of APC2 by RNAi results in transcription-independent accumulation of Mdm2 and attenuation of stress-induced p53 stabilization, leading to decreased senescence and increased cell survival. Furthermore, APC2 expression is frequently downregulated in human cancers; in tumor cell lines, APC2 downregulation correlates with Mdm2 overexpression. Our study shows the regulation of Mdm2 by the E3 ubiquitin ligase APC/C and has important therapeutic implications for tumors with Mdm2 overexpression. Twit Text FOAVip The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2 ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=24804778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24804778 #FOAvip English Wikipedia <ref>{{Cite pmid|24804778}}</ref> The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2 #MMPMID24804778 He Y; Tollini L; Kim TH; Itahana Y; Zhang Y Cell Cycle 2014[Jul]; 13 (13): 2101-9 PMID24804778show ga The Mdm2 proto-oncoprotein is the primary negative regulator for p53. While it is believed that Mdm2 degradation is regulated via its own E3 ubiquitin ligase activity, recent development of knock-in mouse models demonstrates that Mdm2 E3 ligase function is dispensable for self-degradation in vivo. Here, we show that the anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase for Mdm2 degradation. We demonstrate that APC2, a scaffold subunit of APC/C, binds to Mdm2 and is required for Mdm2 polyubiquitination and proteasomal degradation. Downregulation of APC2 by RNAi results in transcription-independent accumulation of Mdm2 and attenuation of stress-induced p53 stabilization, leading to decreased senescence and increased cell survival. Furthermore, APC2 expression is frequently downregulated in human cancers; in tumor cell lines, APC2 downregulation correlates with Mdm2 overexpression. Our study shows the regulation of Mdm2 by the E3 ubiquitin ligase APC/C and has important therapeutic implications for tumors with Mdm2 overexpression. äThe anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for(epmc).pdf DeepDyve Pubget Overpricing