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10.1161/ATVBAHA.113.303134 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.113.303134 C4111131!4111131!24812324     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2014 ; 34 (7): 1412-21 Nephropedia Template TP {{tp|p=24812324|t=2014. Prevention of abdominal aortic aneurysm by anti-miRNA-712 or anti-miR-205 in Angiotensin II infused mice |pdf=|usr=}}{{24812324}} gab.com Text Prevention of abdominal aortic aneurysm by anti-miRNA-712 or anti-miR-205 in Angiotensin II infused mice JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24812324 #FOAvip Objective: Abdominal aortic aneurysm (AAA) is characterized as a progressive dilation and degradation of the aortic wall, associated with activation of matrix metalloproteinases (MMPs) and inflammation. Emerging evidence indicates a role for microRNAs (miRNAs) in AAA pathogenesis, but it is unclear whether abdominal aortic endothelial miRNAs play a role in the disease process. We aimed to identify miRNAs in the abdominal aortic endothelium that play a critical role in AAA development. Approach and Results: The mouse model of AAA induced by Angiotensin II infusion was used in this study.Through a miRNA array and validation study, we initially identified the murine-specific miR-712 and subsequently its human/murine homolog miR-205 as Angiotensin II (AngII)-induced miRNAs in the abdominal aortic endothelium in vivo and in vitro. Mechanistically, miR-712 stimulated MMP activity in the aortic wall by directly targeting two MMP inhibitors:tissue inhibitor of metalloproteinase 3 (TIMP3) and reversion inducing cysteine-rich protein with kazal motifs (RECK). Silencing of miR-712 and miR-205 by using anti-miR-712 and anti-miR-205, respectively, significantly decreased the aortic MMP activity and inflammation, preventing AAA development in AngII-infused ApoE-/- mice. Further, upregulation of four AngII-sensitive miRNAs, miR-205, -21, -133b and -378, identified in this murine study were confirmed in human AAA samples compared to non-diseased control. Conclusions: Our results demonstrate that AngII-sensitive miR-712 and its human homolog miR-205, downregulate TIMP3 and RECK, which in turn stimulate aortic MMP activity and inflammation, leading to AAA development.Targeting these miRNAs may be a novel therapeutic strategy to prevent AAA. Twit Text FOAVip Prevention of abdominal aortic aneurysm by anti-miRNA-712 or anti-miR-205 in Angiotensin II infused mice ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=24812324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24812324 #FOAvip English Wikipedia <ref>{{Cite pmid|24812324}}</ref> Prevention of abdominal aortic aneurysm by anti-miRNA-712 or anti-miR-205 in Angiotensin II infused mice #MMPMID24812324 Kim CW; Kumar S; Son DJ; Jang IH; Griendling KK; Jo H Arterioscler Thromb Vasc Biol 2014[Jul]; 34 (7): 1412-21 PMID24812324show ga Objective: Abdominal aortic aneurysm (AAA) is characterized as a progressive dilation and degradation of the aortic wall, associated with activation of matrix metalloproteinases (MMPs) and inflammation. Emerging evidence indicates a role for microRNAs (miRNAs) in AAA pathogenesis, but it is unclear whether abdominal aortic endothelial miRNAs play a role in the disease process. We aimed to identify miRNAs in the abdominal aortic endothelium that play a critical role in AAA development. Approach and Results: The mouse model of AAA induced by Angiotensin II infusion was used in this study.Through a miRNA array and validation study, we initially identified the murine-specific miR-712 and subsequently its human/murine homolog miR-205 as Angiotensin II (AngII)-induced miRNAs in the abdominal aortic endothelium in vivo and in vitro. Mechanistically, miR-712 stimulated MMP activity in the aortic wall by directly targeting two MMP inhibitors:tissue inhibitor of metalloproteinase 3 (TIMP3) and reversion inducing cysteine-rich protein with kazal motifs (RECK). Silencing of miR-712 and miR-205 by using anti-miR-712 and anti-miR-205, respectively, significantly decreased the aortic MMP activity and inflammation, preventing AAA development in AngII-infused ApoE-/- mice. Further, upregulation of four AngII-sensitive miRNAs, miR-205, -21, -133b and -378, identified in this murine study were confirmed in human AAA samples compared to non-diseased control. Conclusions: Our results demonstrate that AngII-sensitive miR-712 and its human homolog miR-205, downregulate TIMP3 and RECK, which in turn stimulate aortic MMP activity and inflammation, leading to AAA development.Targeting these miRNAs may be a novel therapeutic strategy to prevent AAA. äPrevention of abdominal aortic aneurysm by anti-miRNA-712 or anti-miR-(epmc).pdf DeepDyve Pubget Overpricing