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10.1016/j.cell.2014.04.047 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.04.047 C4110908!4110908!24995982     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 158 (1): 110-20 Nephropedia Template TP {{tp|p=24995982|t=2014. Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation |pdf=|usr=}}{{24995982}} gab.com Text Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24995982 #FOAvip The transcription of genomic information in eukaryotes is regulated in large part by chromatin. How a diverse array of chromatin regulator (CR) proteins with different functions and genomic localization patterns coordinates chromatin activity to control transcription remains unclear. Here we take a synthetic biology approach to decipher the complexity of chromatin regulation by studying emergent transcriptional behaviors from engineered combinatorial, spatial, and temporal patterns of individual CRs. We fuse 223 yeast CRs to programmable zinc finger proteins. Site-specific and combinatorial recruitment of CRs to distinct intra-locus locations reveals a range of transcriptional logic and behaviors, including synergistic activation, long-range and spatial regulation, and gene expression memory. Comparing these transcriptional behaviors with annotated CR complex and function terms provides design principles for the engineering of transcriptional regulation. This work presents a bottom-up approach to investigating chromatin-mediated transcriptional regulation, and introduces new, chromatin-based components and systems for synthetic biology and cellular engineering. Twit Text FOAVip Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24995982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24995982 #FOAvip English Wikipedia <ref>{{Cite pmid|24995982}}</ref> Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation #MMPMID24995982 Keung AJ; Bashor CJ; Kiriakov S; Collins JJ; Khalil AS Cell 2014[Jul]; 158 (1): 110-20 PMID24995982show ga The transcription of genomic information in eukaryotes is regulated in large part by chromatin. How a diverse array of chromatin regulator (CR) proteins with different functions and genomic localization patterns coordinates chromatin activity to control transcription remains unclear. Here we take a synthetic biology approach to decipher the complexity of chromatin regulation by studying emergent transcriptional behaviors from engineered combinatorial, spatial, and temporal patterns of individual CRs. We fuse 223 yeast CRs to programmable zinc finger proteins. Site-specific and combinatorial recruitment of CRs to distinct intra-locus locations reveals a range of transcriptional logic and behaviors, including synergistic activation, long-range and spatial regulation, and gene expression memory. Comparing these transcriptional behaviors with annotated CR complex and function terms provides design principles for the engineering of transcriptional regulation. This work presents a bottom-up approach to investigating chromatin-mediated transcriptional regulation, and introduces new, chromatin-based components and systems for synthetic biology and cellular engineering. äUsing targeted chromatin regulators to engineer combinatorial and spat(epmc).pdf DeepDyve Pubget Overpricing