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10.1074/jbc.M114.547828 http://scihub22266oqcxt.onion/10.1074/jbc.M114.547828 C4110281!4110281 !24898249     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24898249 &cmd=llinks): Failed to open stream: HTTP request failed! 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Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation |pdf=|usr=}}{{24898249 }} gab.com Text Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24898249 #FOAvip Initial steps in protein synthesis are highly regulated processes as they define the reading frame of the translation machinery. Eukaryotic translation initiation is a process facilitated by numerous factors (eIFs), aimed to form a "scanning" mechanism toward the initiation codon. Translation initiation of the main open reading frame (ORF) in an mRNA transcript has been reported to be regulated by upstream open reading frames (uORFs) in a manner of re-initiation. This mode of regulation is governed by the phosphorylation status of eIF2? and controlled by cellular stresses. Another mode of translational initiation regulation is leaky scanning, and this regulatory process has not been extensively studied. We have identified arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions. AIRAP transcript contains a single uORF in a poor-kozak context. AIRAP translation induction is governed by means of leaky scanning and not re-initiation. This induction of AIRAP is solely dependent on eIF1 and the uORF kozak context. We show that eIF1 is phosphorylated under specific conditions that induce protein misfolding and have biochemically characterized this site of phosphorylation. Our data indicate that leaky scanning like re-initiation is responsive to stress conditions and that leaky scanning can induce ORF translation by bypassing poor kozak context of a single uORF transcript. Twit Text FOAVip Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24898249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24898249 #FOAvip English Wikipedia <ref>{{Cite pmid|24898249 }}</ref> Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation #MMPMID24898249 Zach L ; Braunstein I ; Stanhill A J Biol Chem 2014[Jul]; 289 (30 ): 20706-16 PMID24898249 show ga Initial steps in protein synthesis are highly regulated processes as they define the reading frame of the translation machinery. Eukaryotic translation initiation is a process facilitated by numerous factors (eIFs), aimed to form a "scanning" mechanism toward the initiation codon. Translation initiation of the main open reading frame (ORF) in an mRNA transcript has been reported to be regulated by upstream open reading frames (uORFs) in a manner of re-initiation. This mode of regulation is governed by the phosphorylation status of eIF2? and controlled by cellular stresses. Another mode of translational initiation regulation is leaky scanning, and this regulatory process has not been extensively studied. We have identified arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions. AIRAP transcript contains a single uORF in a poor-kozak context. AIRAP translation induction is governed by means of leaky scanning and not re-initiation. This induction of AIRAP is solely dependent on eIF1 and the uORF kozak context. We show that eIF1 is phosphorylated under specific conditions that induce protein misfolding and have biochemically characterized this site of phosphorylation. Our data indicate that leaky scanning like re-initiation is responsive to stress conditions and that leaky scanning can induce ORF translation by bypassing poor kozak context of a single uORF transcript. |Animals [MESH] |Cell Line [MESH] |Eukaryotic Initiation Factor-2/genetics/*metabolism [MESH] |Eukaryotic Initiation Factors/genetics/*metabolism [MESH] |Humans [MESH] |Mice [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |Peptide Chain Initiation, Translational/*physiology [MESH] |Phosphorylation/physiology [MESH] |RNA-Binding Proteins/*biosynthesis/genetics [MESH]Stress-induced start codon fidelity regulates arsenite-inducible regul(epmc).pdf DeepDyve Pubget Overpricing