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10.1002/jez.b.22558 http://scihub22266oqcxt.onion/10.1002/jez.b.22558 C4110200!4110200!24464682     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Zool+B+Mol+Dev+Evol 2014 ; 322 (6): 438-63 Nephropedia Template TP {{tp|p=24464682|t=2014. Genome complexity in the coelacanth is reflected in its adaptive immune system |pdf=|usr=}}{{24464682}} gab.com Text Genome complexity in the coelacanth is reflected in its adaptive immune system JO: J Exp Zool B Mol Dev Evol http://www.kidney.de/pget.php?&tw=1&pmid=24464682 #FOAvip We have analyzed the available genome and transcriptome resources from the coelacanth in order to characterize genes involved in adaptive immunity. Two highly distinctive IgW-encoding loci have been identified that exhibit a unique genomic organization, including a multiplicity of tandemly repeated constant region exons. The overall organization of the IgW loci precludes typical heavy chain class switching. A locus encoding IgM could not be identified either computationally or by using several different experimental strategies. Four distinct sets of genes encoding Ig light chains were identified. This includes a variant sigma-type Ig light chain previously identified only in cartilaginous fishes and which is now provisionally denoted sigma-2. Genes encoding ?/? and ?/? T-cell receptors, and CD3, CD4 and CD8 co-receptors also were characterized. Ig heavy chain variable region genes and TCR components are interspersed within the TCR ?/? locus; this organization previously was reported only in tetrapods and raises questions regarding evolution and functional cooption of genes encoding variable regions. The composition, organization and syntenic conservation of the major histocompatibility complex locus have been characterized. We also identified large numbers of genes encoding cytokines and their receptors, and other genes associated with adaptive immunity. In terms of sequence identity and organization, the adaptive immune genes of the coelacanth more closely resemble orthologous genes in tetrapods than those in teleost fishes, consistent with current phylogenomic interpretations. Overall, the work reported described herein highlights the complexity inherent in the coelacanth genome and provides a rich catalog of immune genes for future investigations. Twit Text FOAVip Genome complexity in the coelacanth is reflected in its adaptive immune system ????J Exp Zool B Mol Dev Evol http://www.kidney.de/pget.php?&tw=1&pmid=24464682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24464682 #FOAvip English Wikipedia <ref>{{Cite pmid|24464682}}</ref> Genome complexity in the coelacanth is reflected in its adaptive immune system #MMPMID24464682 Saha NR; Ota T; Litman GW; Hansen J; Parra Z; Hsu E; Buonocore F; Canapa A; Cheng JF; Amemiya CT J Exp Zool B Mol Dev Evol 2014[Sep]; 322 (6): 438-63 PMID24464682show ga We have analyzed the available genome and transcriptome resources from the coelacanth in order to characterize genes involved in adaptive immunity. Two highly distinctive IgW-encoding loci have been identified that exhibit a unique genomic organization, including a multiplicity of tandemly repeated constant region exons. The overall organization of the IgW loci precludes typical heavy chain class switching. A locus encoding IgM could not be identified either computationally or by using several different experimental strategies. Four distinct sets of genes encoding Ig light chains were identified. This includes a variant sigma-type Ig light chain previously identified only in cartilaginous fishes and which is now provisionally denoted sigma-2. Genes encoding ?/? and ?/? T-cell receptors, and CD3, CD4 and CD8 co-receptors also were characterized. Ig heavy chain variable region genes and TCR components are interspersed within the TCR ?/? locus; this organization previously was reported only in tetrapods and raises questions regarding evolution and functional cooption of genes encoding variable regions. The composition, organization and syntenic conservation of the major histocompatibility complex locus have been characterized. We also identified large numbers of genes encoding cytokines and their receptors, and other genes associated with adaptive immunity. In terms of sequence identity and organization, the adaptive immune genes of the coelacanth more closely resemble orthologous genes in tetrapods than those in teleost fishes, consistent with current phylogenomic interpretations. Overall, the work reported described herein highlights the complexity inherent in the coelacanth genome and provides a rich catalog of immune genes for future investigations. äGenome complexity in the coelacanth is reflected in its adaptive immun(epmc).pdf DeepDyve Pubget Overpricing