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10.1039/c3cs60431d

http://scihub22266oqcxt.onion/10.1039/c3cs60431d
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C4110197!4110197 !24464312
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suck abstract from ncbi


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pmid24464312
      Chem+Soc+Rev 2014 ; 43 (19 ): 6692-700
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  • Differences between amyloid-? aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer s disease #MMPMID24464312
  • Kotler SA ; Walsh P ; Brender JR ; Ramamoorthy A
  • Chem Soc Rev 2014[Oct]; 43 (19 ): 6692-700 PMID24464312 show ga
  • The association of the amyloid-? (A?) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins and peptides, as is the case with A?, follows a progression from a monomeric state, through intermediates, ending at long, unbranched amyloid fibers. This tutorial review offers a perspective on the association of toxic A? structures with membranes as well as details of membrane-associated mechanisms of toxicity.
  • |Alzheimer Disease/metabolism/*pathology [MESH]
  • |Amyloid beta-Peptides/chemistry/*metabolism [MESH]
  • |Cell Membrane/chemistry/*metabolism [MESH]
  • |Gangliosides/chemistry/metabolism [MESH]
  • |Humans [MESH]
  • |Protein Structure, Secondary [MESH]


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