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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Chem+Soc+Rev
2014 ; 43
(19
): 6692-700
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Differences between amyloid-? aggregation in solution and on the membrane:
insights into elucidation of the mechanistic details of Alzheimer s disease
#MMPMID24464312
Kotler SA
; Walsh P
; Brender JR
; Ramamoorthy A
Chem Soc Rev
2014[Oct]; 43
(19
): 6692-700
PMID24464312
show ga
The association of the amyloid-? (A?) peptide with cellular membranes is
hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's
disease. Misfolding of proteins and peptides, as is the case with A?, follows a
progression from a monomeric state, through intermediates, ending at long,
unbranched amyloid fibers. This tutorial review offers a perspective on the
association of toxic A? structures with membranes as well as details of
membrane-associated mechanisms of toxicity.