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10.1002/hep.27157 http://scihub22266oqcxt.onion/10.1002/hep.27157 C4110177!4110177!24700436     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepatology 2014 ; 60 (2): 679-86 Nephropedia Template TP {{tp|p=24700436|t=2014. The Spectrum of Statin Hepatotoxicity: Experience of the Drug Induced Liver Injury Network |pdf=|usr=}}{{24700436}} gab.com Text The Spectrum of Statin Hepatotoxicity: Experience of the Drug Induced Liver Injury Network JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=24700436 #FOAvip Background and Aims: The HMG-CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent liver injury due to statins. Methods: Among 1188 cases of drug-induced liver injury enrolled between 2004 and 2012 in a prospective registry by the U.S. Drug Induced Liver Injury Network, 22 were attributed to a statin. All patients were evaluated in a standard fashion and followed for at least 6 months after onset. Results: The median age was 60 years (range 41 ? 80), and 15 (68%) were female. The latency to onset of liver injury ranged from 34 days to 10 years (median =155 days). Median peak levels were ALT 892 U/L, alkaline phosphatase 358 U/L and total bilirubin 6.1 mg/dL. Nine patients presented with cholestatic hepatitis and 12 patients presented with hepatocellular injury of which 6 had an autoimmune phenotype. Nine patients were hospitalized, 4 developed evidence of hepatic failure and 1 died. All commonly used statins were implicated. Four patients developed chronic liver injury of which three had an autoimmune phenotype of liver injury. Conclusion: Drug induced liver injury from statins is rare and characterized by variable patterns of injury, a range of latencies to onset, autoimmune features in some cases, and persistent or chronic injury in 18% of patients most of whom have an autoimmune phenotype. Twit Text FOAVip The Spectrum of Statin Hepatotoxicity: Experience of the Drug Induced Liver Injury Network ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=24700436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24700436 #FOAvip English Wikipedia <ref>{{Cite pmid|24700436}}</ref> The Spectrum of Statin Hepatotoxicity: Experience of the Drug Induced Liver Injury Network #MMPMID24700436 Russo MW; Hoofnagle JH; Gu J; Fontana RJ; Barnhart H; Kleiner DE; Chalasani N; Bonkovsky HL Hepatology 2014[Aug]; 60 (2): 679-86 PMID24700436show ga Background and Aims: The HMG-CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent liver injury due to statins. Methods: Among 1188 cases of drug-induced liver injury enrolled between 2004 and 2012 in a prospective registry by the U.S. Drug Induced Liver Injury Network, 22 were attributed to a statin. All patients were evaluated in a standard fashion and followed for at least 6 months after onset. Results: The median age was 60 years (range 41 ? 80), and 15 (68%) were female. The latency to onset of liver injury ranged from 34 days to 10 years (median =155 days). Median peak levels were ALT 892 U/L, alkaline phosphatase 358 U/L and total bilirubin 6.1 mg/dL. Nine patients presented with cholestatic hepatitis and 12 patients presented with hepatocellular injury of which 6 had an autoimmune phenotype. Nine patients were hospitalized, 4 developed evidence of hepatic failure and 1 died. All commonly used statins were implicated. Four patients developed chronic liver injury of which three had an autoimmune phenotype of liver injury. Conclusion: Drug induced liver injury from statins is rare and characterized by variable patterns of injury, a range of latencies to onset, autoimmune features in some cases, and persistent or chronic injury in 18% of patients most of whom have an autoimmune phenotype. äThe Spectrum of Statin Hepatotoxicity: Experience of the Drug Induced (epmc).pdf DeepDyve Pubget Overpricing