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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Endocrinol+Metab 2014 ; 25 (7): 337-47 Nephropedia Template TP
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Steroid Receptor Coactivators: Servants and Masters for Control of Systems Metabolism #MMPMID24953190
Stashi E; York B; O?Malley BW
Trends Endocrinol Metab 2014[Jul]; 25 (7): 337-47 PMID24953190show ga
Coregulator recruitment to nuclear receptors (NRs) and other transcription factors is essential for proper metabolic gene regulation with coactivators enhancing and corepressors attenuating gene transcription. The Steroid Receptor Coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions. An accumulating body of work highlights the diverse array of metabolic functions regulated by the SRCs, including systemic metabolite homeostasis, inflammation, and energy regulation. Here we discuss the cooperative and unique functions among the SRCs to provide a comprehensive atlas of systemic SRC metabolic regulation. Deciphering the fractional and synergistic contributions of the SRCs to metabolic homeostasis is critical to fully understand the networks underlying metabolic transcriptional regulation.