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10.1016/j.tips.2014.04.011

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C4108072!4108072!24881011
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suck abstract from ncbi


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pmid24881011      Trends+Pharmacol+Sci 2014 ; 35 (7): 349-57
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  • The therapeutic value of targeting inflammation in gastrointestinal cancers #MMPMID24881011
  • Sun B; Karin M
  • Trends Pharmacol Sci 2014[Jul]; 35 (7): 349-57 PMID24881011show ga
  • Inflammation has been implicated in the initiation and progression of gastrointestinal (GI) cancers. Inflammation also plays important roles in subverting immune tolerance, escape from immune surveillance, and conferring resistance to chemotherapeutic agents. Targeting key regulators and mediators of inflammation represents an attractive strategy for GI cancer prevention and treatment. However, the targeting of inflammation in GI cancer is not straight-forward and sometimes inflammation may contribute to tumor regression. We discuss the origins and effects of inflammation in GI cancer and how to target it successfully.
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