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10.1053/j.seminhematol.2014.05.004 http://scihub22266oqcxt.onion/10.1053/j.seminhematol.2014.05.004 C4107366!4107366!25048782     free     free     free       Semin+Hematol 2014 ; 51 (3): 177-87 Nephropedia Template TP {{tp|p=25048782|t=2014. Evolving Understanding of the CLL Genome |pdf=|usr=}}{{25048782}} gab.com Text Evolving Understanding of the CLL Genome JO: Semin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25048782 #FOAvip Over the past few years, massively parallel sequencing technologies have revealed with high resolution the tremendous genetic and epigenetic heterogeneity in chronic lymphocytic leukemia (CLL). We have learned how the molecular architecture differs not only between affected individuals but also within samples and over time. These insights have catalyzed our understanding of the pathobiology of CLL and point to critical signaling pathways in the development and progression of the disease. Several key driver alterations have been identified, which serve to refine prognostic schemata but also inspire the development of new therapeutic strategies. Ongoing advances in technology promise to further elucidate the molecular basis of CLL, and this knowledge is anticipated to aid us in understanding and addressing the clinical challenge presented by the vast variability in the clinical course of patients with CLL. Twit Text FOAVip Evolving Understanding of the CLL Genome ????Semin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25048782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25048782 #FOAvip English Wikipedia <ref>{{Cite pmid|25048782}}</ref> Evolving Understanding of the CLL Genome #MMPMID25048782 Gruber M; Wu CJ Semin Hematol 2014[Jul]; 51 (3): 177-87 PMID25048782show ga Over the past few years, massively parallel sequencing technologies have revealed with high resolution the tremendous genetic and epigenetic heterogeneity in chronic lymphocytic leukemia (CLL). We have learned how the molecular architecture differs not only between affected individuals but also within samples and over time. These insights have catalyzed our understanding of the pathobiology of CLL and point to critical signaling pathways in the development and progression of the disease. Several key driver alterations have been identified, which serve to refine prognostic schemata but also inspire the development of new therapeutic strategies. Ongoing advances in technology promise to further elucidate the molecular basis of CLL, and this knowledge is anticipated to aid us in understanding and addressing the clinical challenge presented by the vast variability in the clinical course of patients with CLL. äEvolving Understanding of the CLL Genome (epmc).pdf DeepDyve Pubget Overpricing