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10.1002/adhm.201300573 http://scihub22266oqcxt.onion/10.1002/adhm.201300573 C4107175!4107175!24497465     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Healthc+Mater 2014 ; 3 (7): 1061-70 Nephropedia Template TP {{tp|p=24497465|t=2014. Long-term Survival of Allograft Murine Islets Coated via Covalently Stabilized Polymers |pdf=|usr=}}{{24497465}} gab.com Text Long-term Survival of Allograft Murine Islets Coated via Covalently Stabilized Polymers JO: Adv Healthc Mater http://www.kidney.de/pget.php?&tw=1&pmid=24497465 #FOAvip Clinical islet transplantation (CIT) has emerged as a promising treatment option for type 1 diabetes mellitus (T1DM); however, the anti-rejection drug regimen necessary to mitigate allograft islet rejection is undesirable. The use of polymeric coatings to immunocamouflage the transplant from host immune attack has great potential. We have recently developed alginate and poly(ethylene glycol) (PEG)-based polymers, functionalized with azide and phosphine, respectively, which form spontaneous and chemoselective crosslinks via the bioorthogonal Staudinger ligation scheme. Herein, we explored the utility of these polymers to form immunoprotective, ultrathin coatings on murine primary pancreatic islets. Resulting coatings were nontoxic, with unimpaired glucose stimulated insulin secretion. Transplantation of coated BALB/c (H-2d) islets into streptozotozin-induced diabetic C57BL/6 (H-2b) resulted in prompt achievement of normoglycemia, at a rate comparable to controls. A significant subset of animals receiving coated islets (57%) exhibited long-term (> 100 d) function, with robust islets observed upon explantation. Control islets rejected after 15 d (+/? 9 d). Results illustrate the capacity of chemoselectively functionalized polymers to form coatings on islets, imparting no detrimental effect to the underlying cells, with resulting coatings exhibiting significant protective effects in an allograft murine model. Twit Text FOAVip Long-term Survival of Allograft Murine Islets Coated via Covalently Stabilized Polymers ????Adv Healthc Mater http://www.kidney.de/pget.php?&tw=1&pmid=24497465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24497465 #FOAvip English Wikipedia <ref>{{Cite pmid|24497465}}</ref> Long-term Survival of Allograft Murine Islets Coated via Covalently Stabilized Polymers #MMPMID24497465 Rengifo HR; Giraldo JA; Labrada I; Stabler CL Adv Healthc Mater 2014[Jul]; 3 (7): 1061-70 PMID24497465show ga Clinical islet transplantation (CIT) has emerged as a promising treatment option for type 1 diabetes mellitus (T1DM); however, the anti-rejection drug regimen necessary to mitigate allograft islet rejection is undesirable. The use of polymeric coatings to immunocamouflage the transplant from host immune attack has great potential. We have recently developed alginate and poly(ethylene glycol) (PEG)-based polymers, functionalized with azide and phosphine, respectively, which form spontaneous and chemoselective crosslinks via the bioorthogonal Staudinger ligation scheme. Herein, we explored the utility of these polymers to form immunoprotective, ultrathin coatings on murine primary pancreatic islets. Resulting coatings were nontoxic, with unimpaired glucose stimulated insulin secretion. Transplantation of coated BALB/c (H-2d) islets into streptozotozin-induced diabetic C57BL/6 (H-2b) resulted in prompt achievement of normoglycemia, at a rate comparable to controls. A significant subset of animals receiving coated islets (57%) exhibited long-term (> 100 d) function, with robust islets observed upon explantation. Control islets rejected after 15 d (+/? 9 d). Results illustrate the capacity of chemoselectively functionalized polymers to form coatings on islets, imparting no detrimental effect to the underlying cells, with resulting coatings exhibiting significant protective effects in an allograft murine model. äLong-term Survival of Allograft Murine Islets Coated via Covalently St(epmc).pdf DeepDyve Pubget Overpricing