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10.1016/j.bbrc.2014.06.074 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2014.06.074 C4107148!4107148!24971542     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24971542&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2014 ; 450 (1): 851-6 Nephropedia Template TP {{tp|p=24971542|t=2014. HMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activation through RAGE |pdf=|usr=}}{{24971542}} gab.com Text HMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activation through RAGE JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=24971542 #FOAvip High mobility group box 1 (HMGB1) is a prototype damage-associated molecular pattern (DAMP) that can induce inflammatory and immune responses alone as well as in combination with other molecules such as DNA. However, the intricate molecular mechanisms underlying HMGB1-DNA complex-mediated innate immune response remains largely elusive. In this study, we demonstrated that HMGB1-DNA complex initially induced absent in melanoma 2 (AIM2)-dependent inflammasome activation, and promoted rapid release of inflammasome-dependent early proinflammatory cytokines such as interleukin 1? (IL-1?). Subsequently, HMGB1-DNA complex stimulated an ATG5-dependent cellular degradation process, autophagy, which was paralleled by a cessation of AIM2 inflammasome activation and IL-1? release. These HMGB1-DNA complex-induced inflammasome activation and autophagy were both dependent on the receptor for advanced glycation endproducts (RAGE) that recognizes a wide array of ligands (including HMGB1 and DNA). Thus, autophagy may function as a negative counter-regulatory mechanism for HMGB1-DNA complex-induced inflammasome activation, and provide a checkpoint to limit the development of inflammation. Twit Text FOAVip HMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activation through RAGE ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=24971542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971542 #FOAvip English Wikipedia <ref>{{Cite pmid|24971542}}</ref> HMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activation through RAGE #MMPMID24971542 Liu L; Yang M; Kang R; Yu Y; Dai Y; Gao F; Wang H; Sun X; Li X; Li J; Wang H; Cao L; Tang D Biochem Biophys Res Commun 2014[Jul]; 450 (1): 851-6 PMID24971542show ga High mobility group box 1 (HMGB1) is a prototype damage-associated molecular pattern (DAMP) that can induce inflammatory and immune responses alone as well as in combination with other molecules such as DNA. However, the intricate molecular mechanisms underlying HMGB1-DNA complex-mediated innate immune response remains largely elusive. In this study, we demonstrated that HMGB1-DNA complex initially induced absent in melanoma 2 (AIM2)-dependent inflammasome activation, and promoted rapid release of inflammasome-dependent early proinflammatory cytokines such as interleukin 1? (IL-1?). Subsequently, HMGB1-DNA complex stimulated an ATG5-dependent cellular degradation process, autophagy, which was paralleled by a cessation of AIM2 inflammasome activation and IL-1? release. These HMGB1-DNA complex-induced inflammasome activation and autophagy were both dependent on the receptor for advanced glycation endproducts (RAGE) that recognizes a wide array of ligands (including HMGB1 and DNA). Thus, autophagy may function as a negative counter-regulatory mechanism for HMGB1-DNA complex-induced inflammasome activation, and provide a checkpoint to limit the development of inflammation. äHMGB1-DNA Complex-induced Autophagy Limits AIM2 Inflammasome Activatio(epmc).pdf DeepDyve Pubget Overpricing