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10.1074/jbc.M114.554691

http://scihub22266oqcxt.onion/10.1074/jbc.M114.554691
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C4106343!4106343!24878958
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suck abstract from ncbi


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pmid24878958      J+Biol+Chem 2014 ; 289 (29): 20295-306
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  • Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis* #MMPMID24878958
  • Alhasan AA; Spielhofer J; Kusche-Gullberg M; Kirby JA; Ali S
  • J Biol Chem 2014[Jul]; 289 (29): 20295-306 PMID24878958show ga
  • Background: Heparan sulfate (HS) plays a role in renal fibrosis.Results: 6-O-sulfation of HS was increased after kidney transplantation, leading to the sequestration and activation of FGF2.Conclusion: Increased 6-O-sulfation of HS regulates the fibrotic response associated with chronic renal allograft failure.Significance: Blockade of the interaction between FGF2 and 6-O-sulfated HS might mitigate the development of renal fibrosis.
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