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10.1074/jbc.M113.544494

http://scihub22266oqcxt.onion/10.1074/jbc.M113.544494
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C4106337!4106337!24867951
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suck abstract from ncbi


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pmid24867951      J+Biol+Chem 2014 ; 289 (29): 20209-21
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  • Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth #MMPMID24867951
  • Birukawa NK; Murase K; Sato Y; Kosaka A; Yoneda A; Nishita H; Fujita R; Nishimura M; Ninomiya T; Kajiwara K; Miyazaki M; Nakashima Y; Ota S; Murakami Y; Tanaka Y; Minomi K; Tamura Y; Niitsu Y
  • J Biol Chem 2014[Jul]; 289 (29): 20209-21 PMID24867951show ga
  • Background: The mechanisms of apoptosis induced by antifibrosis therapy in activated hepatic stellate cells (aHSCs), the main collagen producer in cirrhotic livers, are unknown.Results: aHSCs underwent apoptosis by inhibiting the supply of membrane type 1 matrix metalloproteinase (MT1-MMP)-cleaved collagen.Conclusion: aHSCs require MT1-MMP-cleaved collagen for their survival.Significance: Interference with the supply of MT1-MMP-cleaved collagen for aHSCs is a reasonable antifibrosis strategy.
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