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10.1074/jbc.M114.558064

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C4106327!4106327!24867947
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suck abstract from ncbi


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pmid24867947      J+Biol+Chem 2014 ; 289 (29): 20120-8
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  • Epigenetic Modifications and Canonical Wingless/int-1 Class (WNT) Signaling Enable Trans-differentiation of Nonosteogenic Cells into Osteoblasts* #MMPMID24867947
  • Cho YD; Yoon WJ; Kim WJ; Woo KM; Baek JH; Lee G; Ku Y; van Wijnen AJ; Ryoo HM
  • J Biol Chem 2014[Jul]; 289 (29): 20120-8 PMID24867947show ga
  • Background: The cell type-specific induction of Bmp2 expression by Wnt3a indicates that Bmp2 is controlled by epigenetic mechanisms.Results: Epigenetic modification activates Bmp2 and Alp expression by Wnt3a in nonosteogenic cells.Conclusion: Epigenetic induction of Bmp2 production by Wnt3a reveals a new mechanistic dimension in morphogen-mediated control of osteogenesis.Significance: Epigenetic modifications/canonical Wnt3a signaling may provide a new method for trans-differentiation of nonosteogenic cells to osteoblasts.
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