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10.1016/j.immuni.2014.05.005 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.05.005 C4105986!4105986 !24931122     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24931122 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2014 ; 40 (6 ): 974-88 Nephropedia Template TP {{tp|p=24931122 |t=2014. Memory-T-cell-derived interferon-? instructs potent innate cell activation for protective immunity |pdf=|usr=}}{{24931122 }} gab.com Text Memory-T-cell-derived interferon- instructs potent innate cell activation for protective immunity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24931122 #FOAvip Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that memory T cells instruct innate cells to become potent effector cells in a systemic and a mucosal model of infection. Memory T cells controlled phagocyte, dendritic cell, and NK or NK T cell mobilization and induction of a strong program of differentiation, which included their expression of effector cytokines and microbicidal pathways, all of which were delayed in nonvaccinated hosts. Disruption of IFN-? signaling in Ly6C+ monocytes, dendritic cells, and macrophages impaired these processes and the control of pathogen growth. These results reveal how memory T cells, through rapid secretion of IFN-?, orchestrate extensive modifications of host innate immune responses that are essential for effective protection of vaccinated hosts. Twit Text FOAVip Memory-T-cell-derived interferon- instructs potent innate cell activation for protective immunity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=24931122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24931122 #FOAvip English Wikipedia <ref>{{Cite pmid|24931122 }}</ref> Memory-T-cell-derived interferon-? instructs potent innate cell activation for protective immunity #MMPMID24931122 Soudja SM ; Chandrabos C ; Yakob E ; Veenstra M ; Palliser D ; Lauvau G Immunity 2014[Jun]; 40 (6 ): 974-88 PMID24931122 show ga Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that memory T cells instruct innate cells to become potent effector cells in a systemic and a mucosal model of infection. Memory T cells controlled phagocyte, dendritic cell, and NK or NK T cell mobilization and induction of a strong program of differentiation, which included their expression of effector cytokines and microbicidal pathways, all of which were delayed in nonvaccinated hosts. Disruption of IFN-? signaling in Ly6C+ monocytes, dendritic cells, and macrophages impaired these processes and the control of pathogen growth. These results reveal how memory T cells, through rapid secretion of IFN-?, orchestrate extensive modifications of host innate immune responses that are essential for effective protection of vaccinated hosts. |*Immunologic Memory [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Antigens, Ly [MESH] |CD4-Positive T-Lymphocytes/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cell Differentiation/immunology [MESH] |Cytokines/immunology [MESH] |Dendritic Cells/immunology [MESH] |Female [MESH] |Herpesvirus 2, Human/immunology [MESH] |Immunity, Innate [MESH] |Immunization [MESH] |Interferon gamma Receptor [MESH] |Interferon-gamma/*immunology [MESH] |Killer Cells, Natural/immunology [MESH] |Listeria monocytogenes/immunology [MESH] |Listeriosis/immunology [MESH] |Lymphocyte Activation/*immunology [MESH] |Macrophages/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Monocytes/immunology [MESH] |Natural Killer T-Cells/immunology [MESH] |Phagocytosis/immunology [MESH]Memory-T-cell-derived interferon-? instructs potent innate cell activa(epmc).pdf DeepDyve Pubget Overpricing