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10.1111/bph.12715 http://scihub22266oqcxt.onion/10.1111/bph.12715 C4105938!4105938 !24712652     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24712652 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2014 ; 171 (14 ): 3526-38 Nephropedia Template TP {{tp|p=24712652 |t=2014. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice |pdf=|usr=}}{{24712652 }} gab.com Text Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24712652 #FOAvip BACKGROUND AND PURPOSE: Methyl salicylate 2-O-?-d-lactoside (MSL), whose chemical structure is similar to that of salicylic acid, is a natural product derivative isolated from a traditional Chinese herb. The aim of this study was to investigate the therapeutic effect of MSL in mice with collagen-induced arthritis (CIA) and explore its underlying mechanism. EXPERIMENTAL APPROACH: The anti-arthritic effects of MSL were evaluated on human rheumatoid fibroblast-like synoviocytes (FLS) in vitro and CIA in mice in vivo by obtaining clinical scores, measuring hind paw thickness and inflammatory cytokine levels, radiographic evaluations and histopathological assessments. KEY RESULTS: Treatment with MSL after the onset of arthritis significantly prevented the progression and development of rheumatoid arthritis (RA) in CIA mice without megascopic gastric mucosa damage. In addition, MSL inhibited the production of pro-inflammatory mediators, the phosphorylation and translocation of NF-?B, and cell proliferation induced by TNF-? in FLS. MSL non-selectively inhibited the activity of COX?in vitro, but was a more potent inhibitor of COX-2 than COX-1. MSL also inhibited the phosphorylation of inhibitor of NF-?B kinase, I?B? and p65, thus blocking the nuclear translocation of NF-?B in TNF-?-stimulated FLS. CONCLUSION AND IMPLICATIONS: MSL exerts therapeutic effects on CIA mice, suppressing the inflammatory response and joint destruction by non-selectively inhibiting the activity of COX and suppressing activation of the NF-?B signalling pathway, but without damaging the gastric mucosa. Therefore, MSL has great potential to be developed into a novel therapeutic agent for the treatment of RA. Twit Text FOAVip Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24712652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24712652 #FOAvip English Wikipedia <ref>{{Cite pmid|24712652 }}</ref> Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice #MMPMID24712652 Xin W ; Huang C ; Zhang X ; Xin S ; Zhou Y ; Ma X ; Zhang D ; Li Y ; Zhou S ; Zhang D ; Zhang T ; Du G Br J Pharmacol 2014[Jul]; 171 (14 ): 3526-38 PMID24712652 show ga BACKGROUND AND PURPOSE: Methyl salicylate 2-O-?-d-lactoside (MSL), whose chemical structure is similar to that of salicylic acid, is a natural product derivative isolated from a traditional Chinese herb. The aim of this study was to investigate the therapeutic effect of MSL in mice with collagen-induced arthritis (CIA) and explore its underlying mechanism. EXPERIMENTAL APPROACH: The anti-arthritic effects of MSL were evaluated on human rheumatoid fibroblast-like synoviocytes (FLS) in vitro and CIA in mice in vivo by obtaining clinical scores, measuring hind paw thickness and inflammatory cytokine levels, radiographic evaluations and histopathological assessments. KEY RESULTS: Treatment with MSL after the onset of arthritis significantly prevented the progression and development of rheumatoid arthritis (RA) in CIA mice without megascopic gastric mucosa damage. In addition, MSL inhibited the production of pro-inflammatory mediators, the phosphorylation and translocation of NF-?B, and cell proliferation induced by TNF-? in FLS. MSL non-selectively inhibited the activity of COX?in vitro, but was a more potent inhibitor of COX-2 than COX-1. MSL also inhibited the phosphorylation of inhibitor of NF-?B kinase, I?B? and p65, thus blocking the nuclear translocation of NF-?B in TNF-?-stimulated FLS. CONCLUSION AND IMPLICATIONS: MSL exerts therapeutic effects on CIA mice, suppressing the inflammatory response and joint destruction by non-selectively inhibiting the activity of COX and suppressing activation of the NF-?B signalling pathway, but without damaging the gastric mucosa. Therefore, MSL has great potential to be developed into a novel therapeutic agent for the treatment of RA. |Animals [MESH] |Ankle Joint/*drug effects/metabolism/*pathology [MESH] |Antirheumatic Agents/chemistry/*pharmacology [MESH] |Arthritis, Experimental/chemically induced/*drug therapy/pathology [MESH] |Cell Proliferation/drug effects [MESH] |Collagen [MESH] |Humans [MESH] |Inflammation Mediators/antagonists & inhibitors/metabolism [MESH] |Inflammation/drug therapy/metabolism [MESH] |Lactose/*analogs & derivatives/chemistry/pharmacology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred DBA [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Salicylates/chemistry/*pharmacology [MESH] |Synovial Membrane/*drug effects/metabolism/*pathology [MESH]Methyl salicylate lactoside inhibits inflammatory response of fibrobla(epmc).pdf DeepDyve Pubget Overpricing