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10.1016/j.cub.2014.04.037

http://scihub22266oqcxt.onion/10.1016/j.cub.2014.04.037
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C4104651!4104651!24892918
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suck abstract from ncbi


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pmid24892918      Curr+Biol 2014 ; 24 (11): R535-9
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  • Cohesin and Polycomb: Cooperative Checks and Balances in Gene Silencing and Transcription #MMPMID24892918
  • Dorsett D; Kassis JA
  • Curr Biol 2014[Jun]; 24 (11): R535-9 PMID24892918show ga
  • The cohesin protein complex was discovered for its roles in sister chromatid cohesion and segregation, and the Polycomb group (PcG) proteins for their roles in epigenetic gene silencing during development. Cohesin also controls gene transcription via multiple mechanisms. Genetic and molecular evidence from Drosophila argue that cohesin and the PRC1 PcG complex interact to control transcription of many active genes that are critical for development, and that via these interactions cohesin also controls the availability of PRC1 for gene silencing.
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