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10.1016/j.jprot.2014.03.021

http://scihub22266oqcxt.onion/10.1016/j.jprot.2014.03.021
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C4104210!4104210!24686089
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suck abstract from ncbi


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pmid24686089      J+Proteomics 2014 ; ä (ä): 71-82
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  • MALDI Imaging Mass Spectrometry: Spatial Molecular Analysis to Enable a New Age of Discovery #MMPMID24686089
  • Gessel MM; Norris JL; Caprioli RM
  • J Proteomics 2014[Jul]; ä (ä): 71-82 PMID24686089show ga
  • Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) combines the sensitivity and selectivity of mass spectrometry with spatial analysis to provide a new dimension for histological analyses to provide unbiased visualization of the arrangement of biomolecules in tissue. As such, MALDI IMS has the capability to become a powerful new molecular technology for the biological and clinical sciences. In this review, we briefly describe several applications of MALDI IMS covering a range of molecular weights, from drugs to proteins. Current limitations and challenges are discussed along with recent developments to address these issues.
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