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10.1016/j.ydbio.2014.04.017 http://scihub22266oqcxt.onion/10.1016/j.ydbio.2014.04.017 C4103428!4103428 !24809797     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24809797 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dev+Biol 2014 ; 391 (2 ): 241-50 Nephropedia Template TP {{tp|p=24809797 |t=2014. Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration |pdf=|usr=}}{{24809797 }} gab.com Text Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration JO: Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24809797 #FOAvip Corneal avascularity is important for optical clarity and normal vision. However, the molecular mechanisms that prevent angioblast migration and vascularization of the developing cornea are not clear. Previously we showed that periocular angioblasts and forming ocular blood vessels avoid the presumptive cornea despite dynamic ingression of neural crest cells. In the current study, we investigate the role of Semaphorin3A (Sema3A), a cell guidance chemorepellent, on angioblast migration and corneal avascularity during development. We show that Sema3A, Vegf, and Nrp1 are expressed in the anterior eye during cornea development. Sema3A mRNA transcripts are expressed at significantly higher levels than Vegf in the lens that is positioned adjacent to the presumptive cornea. Blockade of Sema3A signaling via lens removal or injection of a synthetic Sema3A inhibitor causes ectopic migration of angioblasts into the cornea and results in its subsequent vascularization. In addition, using bead implantation, we demonstrate that exogenous Sema3A protein inhibits Vegf-induced vascularization of the cornea. In agreement with these findings, loss of Sema/Nrp1 signaling in Nrp1(Sema-) mutant mice results in ectopic angioblasts and vascularization of the embryonic mouse corneas. Altogether, our results reveal Sema3A signaling as an important cue during the establishment of corneal avascularity in both chick and mouse embryos. Our study introduces cornea development as a new model for studying the mechanisms involved in vascular patterning during embryogenesis and it also provides new insights into therapeutic potential for Sema3A in neovascular diseases. Twit Text FOAVip Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration ????Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24809797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24809797 #FOAvip English Wikipedia <ref>{{Cite pmid|24809797 }}</ref> Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration #MMPMID24809797 McKenna CC ; Ojeda AF ; Spurlin J 3rd ; Kwiatkowski S ; Lwigale PY Dev Biol 2014[Jul]; 391 (2 ): 241-50 PMID24809797 show ga Corneal avascularity is important for optical clarity and normal vision. However, the molecular mechanisms that prevent angioblast migration and vascularization of the developing cornea are not clear. Previously we showed that periocular angioblasts and forming ocular blood vessels avoid the presumptive cornea despite dynamic ingression of neural crest cells. In the current study, we investigate the role of Semaphorin3A (Sema3A), a cell guidance chemorepellent, on angioblast migration and corneal avascularity during development. We show that Sema3A, Vegf, and Nrp1 are expressed in the anterior eye during cornea development. Sema3A mRNA transcripts are expressed at significantly higher levels than Vegf in the lens that is positioned adjacent to the presumptive cornea. Blockade of Sema3A signaling via lens removal or injection of a synthetic Sema3A inhibitor causes ectopic migration of angioblasts into the cornea and results in its subsequent vascularization. In addition, using bead implantation, we demonstrate that exogenous Sema3A protein inhibits Vegf-induced vascularization of the cornea. In agreement with these findings, loss of Sema/Nrp1 signaling in Nrp1(Sema-) mutant mice results in ectopic angioblasts and vascularization of the embryonic mouse corneas. Altogether, our results reveal Sema3A signaling as an important cue during the establishment of corneal avascularity in both chick and mouse embryos. Our study introduces cornea development as a new model for studying the mechanisms involved in vascular patterning during embryogenesis and it also provides new insights into therapeutic potential for Sema3A in neovascular diseases. |Animals [MESH] |Animals, Genetically Modified [MESH] |Cell Movement [MESH] |Cells, Cultured [MESH] |Chick Embryo [MESH] |Cornea/*blood supply/embryology [MESH] |Endothelial Cells [MESH] |Lens, Crystalline/*blood supply/embryology [MESH] |Mice [MESH] |Neovascularization, Physiologic [MESH] |Neuropilin-1/biosynthesis/*genetics [MESH] |Quail/embryology [MESH] |RNA, Messenger/biosynthesis [MESH] |Recombinant Fusion Proteins/genetics [MESH] |Semaphorin-3A/antagonists & inhibitors/genetics/*physiology [MESH] |Signal Transduction [MESH]Sema3A maintains corneal avascularity during development by inhibiting(epmc).pdf DeepDyve Pubget Overpricing