Protein Homeostasis at the Plasma Membrane #MMPMID24985330
Apaja PM; Lukacs GL
Physiology (Bethesda) 2014[Jul]; 29 (4): 265-77 PMID24985330show ga
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.