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10.1182/blood-2014-01-514786 http://scihub22266oqcxt.onion/10.1182/blood-2014-01-514786 C4102709!4102709!24914140     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2014 ; 124 (3): 363-73 Nephropedia Template TP {{tp|p=24914140|t=2014. Acute graft-versus-host disease: a bench-to-bedside update |pdf=|usr=}}{{24914140}} gab.com Text Acute graft-versus-host disease: a bench-to-bedside update JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=24914140 #FOAvip Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need. Twit Text FOAVip Acute graft-versus-host disease: a bench-to-bedside update ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=24914140 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24914140 #FOAvip English Wikipedia <ref>{{Cite pmid|24914140}}</ref> Acute graft-versus-host disease: a bench-to-bedside update #MMPMID24914140 Holtan SG; Pasquini M; Weisdorf DJ Blood 2014[Jul]; 124 (3): 363-73 PMID24914140show ga Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need. äAcute graft-versus-host disease: a bench-to-bedside update (epmc).pdf DeepDyve Pubget Overpricing