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10.1097/TP.0000000000000047 http://scihub22266oqcxt.onion/10.1097/TP.0000000000000047 C4101052!4101052 !24675478     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24675478 &cmd=llinks): Failed to open stream: HTTP request failed! 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The role of donor-specific antibodies in acute cardiac allograft dysfunction in the absence of cellular rejection |pdf=|usr=}}{{24675478 }} gab.com Text The role of donor-specific antibodies in acute cardiac allograft dysfunction in the absence of cellular rejection JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=24675478 #FOAvip BACKGROUND: Acute allograft dysfunction (AAD) is an important cause of morbidity among heart transplant recipients. The role of donor-specific antibodies (DSAs) in AAD, with the increasing use of single antigen bead (SAB) assays that have improved the ability to detect DSA, remains unclear. METHODS: We retrospectively reviewed 329 heart transplant recipients followed up at our institution. AAD was defined as an acute decline in left ventricular ejection fraction to less than 50% and a decrement of 10% or higher compared to baseline in the absence of cellular rejection. Patients with AAD were compared with matched 30 heart transplant controls. RESULTS: There were 10 (3%) patients with AAD, 4 (40%) had DSA detectable by SAB assay compared to 16 (53%) controls (P=0.43). Peak DSA mean fluorescent intensity (MFI) levels were significantly higher at baseline (class I and class II) in AAD compared to controls. DSA MFI values increased at the time of AAD and returned to baseline values during follow-up for these patients with AAD (P<0.05) but remained unchanged over time for controls. Six (60%) patients with AAD and 1 (3%) control had antibody-mediated rejection (AMR) by endomyocardial biopsy (P<0.01). There were 4 (40%) patients with AAD with no DSA or AMR. CONCLUSIONS: AAD after heart transplant is a heterogeneous process characterized by 1) AMR and DSA, 2) AMR but no DSA, and 3) no AMR or DSA. The presence of DSA is not associated with AAD, but the quantity assessed by MFI levels may play a role. Twit Text FOAVip The role of donor-specific antibodies in acute cardiac allograft dysfunction in the absence of cellular rejection ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=24675478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24675478 #FOAvip English Wikipedia <ref>{{Cite pmid|24675478 }}</ref> The role of donor-specific antibodies in acute cardiac allograft dysfunction in the absence of cellular rejection #MMPMID24675478 Fine NM ; Daly RC ; Shankar N ; Park SJ ; Kushwaha SS ; Gandhi MJ ; Pereira NL Transplantation 2014[Jul]; 98 (2 ): 229-38 PMID24675478 show ga BACKGROUND: Acute allograft dysfunction (AAD) is an important cause of morbidity among heart transplant recipients. The role of donor-specific antibodies (DSAs) in AAD, with the increasing use of single antigen bead (SAB) assays that have improved the ability to detect DSA, remains unclear. METHODS: We retrospectively reviewed 329 heart transplant recipients followed up at our institution. AAD was defined as an acute decline in left ventricular ejection fraction to less than 50% and a decrement of 10% or higher compared to baseline in the absence of cellular rejection. Patients with AAD were compared with matched 30 heart transplant controls. RESULTS: There were 10 (3%) patients with AAD, 4 (40%) had DSA detectable by SAB assay compared to 16 (53%) controls (P=0.43). Peak DSA mean fluorescent intensity (MFI) levels were significantly higher at baseline (class I and class II) in AAD compared to controls. DSA MFI values increased at the time of AAD and returned to baseline values during follow-up for these patients with AAD (P<0.05) but remained unchanged over time for controls. Six (60%) patients with AAD and 1 (3%) control had antibody-mediated rejection (AMR) by endomyocardial biopsy (P<0.01). There were 4 (40%) patients with AAD with no DSA or AMR. CONCLUSIONS: AAD after heart transplant is a heterogeneous process characterized by 1) AMR and DSA, 2) AMR but no DSA, and 3) no AMR or DSA. The presence of DSA is not associated with AAD, but the quantity assessed by MFI levels may play a role. |Acute Disease [MESH] |Adult [MESH] |Aged [MESH] |Allografts [MESH] |Biomarkers/blood [MESH] |Biopsy [MESH] |Coronary Angiography [MESH] |Female [MESH] |Graft Rejection/blood/diagnosis/*immunology/prevention & control [MESH] |Heart Transplantation/*adverse effects [MESH] |Humans [MESH] |Immunosuppressive Agents/therapeutic use [MESH] |Isoantibodies/*blood [MESH] |Male [MESH] |Middle Aged [MESH] |Minnesota [MESH] |Retrospective Studies [MESH] |Stroke Volume [MESH] |Time Factors [MESH] |Treatment Outcome [MESH] |Ventricular Dysfunction, Left/blood/diagnosis/*immunology/physiopathology [MESH]The role of donor-specific antibodies in acute cardiac allograft dysfu(epmc).pdf DeepDyve Pubget Overpricing