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10.1016/j.smim.2014.02.009

http://scihub22266oqcxt.onion/10.1016/j.smim.2014.02.009
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C4099309!4099309!24647229
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suck abstract from ncbi

pmid24647229      Semin+Immunol 2014 ; 26 (3): 237-45
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  • TNF and MAP kinase signaling pathways #MMPMID24647229
  • Sabio G; Davis RJ
  • Semin Immunol 2014[Jun]; 26 (3): 237-45 PMID24647229show ga
  • The binding of tumor necrosis factor ? (TNF?) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNF?) that contribute to the biological activity of TNF?. MAP kinases therefore function both upstream and down-stream of signalling by TNF? receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNF?.
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