TNF and MAP kinase signaling pathways #MMPMID24647229
Sabio G; Davis RJ
Semin Immunol 2014[Jun]; 26 (3): 237-45 PMID24647229show ga
The binding of tumor necrosis factor ? (TNF?) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNF?) that contribute to the biological activity of TNF?. MAP kinases therefore function both upstream and down-stream of signalling by TNF? receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNF?.