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10.1177/0885066613517076 http://scihub22266oqcxt.onion/10.1177/0885066613517076 C4099298!4099298!24407034     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Intensive+Care+Med 2015 ; 30 (7): 401-12 Nephropedia Template TP {{tp|p=24407034|t=2015. Hemophagocytic Syndrome and Critical Illness: New insights into Diagnosis and Management |pdf=|usr=}}{{24407034}} gab.com Text Hemophagocytic Syndrome and Critical Illness: New insights into Diagnosis and Management JO: J Intensive Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24407034 #FOAvip Hemophagocytic lymphohistiocytosis (HLH) comprises a heterogeneous group of diseases which are characterized by a hyperinflammatory state due to uncontrolled T cell, macrophage and histiocyte activation, accompanied by excessive cytokine production. This rare condition is almost uniformly fatal unless promptly recognized and treated. Much progress has been made in the last two decades in our understanding of the mechanisms underlying familial, and to a lesser extent, acquired cases of HLH. Recurrent mutations in more than 10 different genes have now been identified, involving biological pathways converging on intracellular vesicle trafficking, and cytolytic granule exocytosis. Mechanisms underlying the majority of acquired HLH cases, however, remain elusive, hampering both diagnostic evaluation as well as therapeutic management of these patients. Given that the majority of intensive care unit (ICU) patients with sepsis or multiorgan failure share many features of HLH, it is especially critical for pediatric and adult intensivists to be able to recognize patients with bona fide HLH and initiate treatment without delay. In this article, we review our current understanding of the pathophysiology, clinical testing, diagnosis, and treatment of patients with HLH, especially as it pertains to the care of critically ill patients in pediatric and medical ICUs. Twit Text FOAVip Hemophagocytic Syndrome and Critical Illness: New insights into Diagnosis and Management ????J Intensive Care Med http://www.kidney.de/pget.php?&tw=1&pmid=24407034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24407034 #FOAvip English Wikipedia <ref>{{Cite pmid|24407034}}</ref> Hemophagocytic Syndrome and Critical Illness: New insights into Diagnosis and Management #MMPMID24407034 Tothova Z; Berliner N J Intensive Care Med 2015[Oct]; 30 (7): 401-12 PMID24407034show ga Hemophagocytic lymphohistiocytosis (HLH) comprises a heterogeneous group of diseases which are characterized by a hyperinflammatory state due to uncontrolled T cell, macrophage and histiocyte activation, accompanied by excessive cytokine production. This rare condition is almost uniformly fatal unless promptly recognized and treated. Much progress has been made in the last two decades in our understanding of the mechanisms underlying familial, and to a lesser extent, acquired cases of HLH. Recurrent mutations in more than 10 different genes have now been identified, involving biological pathways converging on intracellular vesicle trafficking, and cytolytic granule exocytosis. Mechanisms underlying the majority of acquired HLH cases, however, remain elusive, hampering both diagnostic evaluation as well as therapeutic management of these patients. Given that the majority of intensive care unit (ICU) patients with sepsis or multiorgan failure share many features of HLH, it is especially critical for pediatric and adult intensivists to be able to recognize patients with bona fide HLH and initiate treatment without delay. In this article, we review our current understanding of the pathophysiology, clinical testing, diagnosis, and treatment of patients with HLH, especially as it pertains to the care of critically ill patients in pediatric and medical ICUs. äHemophagocytic Syndrome and Critical Illness: New insights into Diagno(epmc).pdf DeepDyve Pubget Overpricing