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2014 ; 98
(ä): 147-58
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Contributions of the cerebellum and the motor cortex to acquisition and retention
of motor memories
#MMPMID24816533
Herzfeld DJ
; Pastor D
; Haith AM
; Rossetti Y
; Shadmehr R
; O'Shea J
Neuroimage
2014[Sep]; 98
(ä): 147-58
PMID24816533
show ga
We investigated the contributions of the cerebellum and the motor cortex (M1) to
acquisition and retention of human motor memories in a force field reaching task.
We found that anodal transcranial direct current stimulation (tDCS) of the
cerebellum, a technique that is thought to increase neuronal excitability,
increased the ability to learn from error and form an internal model of the
field, while cathodal cerebellar stimulation reduced this error-dependent
learning. In addition, cathodal cerebellar stimulation disrupted the ability to
respond to error within a reaching movement, reducing the gain of the
sensory-motor feedback loop. By contrast, anodal M1 stimulation had no
significant effects on these variables. During sham stimulation, early in
training the acquired motor memory exhibited rapid decay in error-clamp trials.
With further training the rate of decay decreased, suggesting that with training
the motor memory was transformed from a labile to a more stable state.
Surprisingly, neither cerebellar nor M1 stimulation altered these decay patterns.
Participants returned 24hours later and were re-tested in error-clamp trials
without stimulation. The cerebellar group that had learned the task with cathodal
stimulation exhibited significantly impaired retention, and retention was not
improved by M1 anodal stimulation. In summary, non-invasive cerebellar
stimulation resulted in polarity-dependent up- or down-regulation of
error-dependent motor learning. In addition, cathodal cerebellar stimulation
during acquisition impaired the ability to retain the motor memory overnight.
Thus, in the force field task we found a critical role for the cerebellum in both
formation of motor memory and its retention.