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10.1016/j.tcm.2014.02.001 http://scihub22266oqcxt.onion/10.1016/j.tcm.2014.02.001 C4099253!4099253!24656989     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Cardiovasc+Med 2014 ; 24 (5): 184-90 Nephropedia Template TP {{tp|p=24656989|t=2014. Desmosomes and the sodium channel complex: implications for Arrhythmogenic Cardiomyopathy and Brugada Syndrome |pdf=|usr=}}{{24656989}} gab.com Text Desmosomes and the sodium channel complex: implications for Arrhythmogenic Cardiomyopathy and Brugada Syndrome JO: Trends Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=24656989 #FOAvip Mutations in proteins of the desmosome associate with arrhythmogenic cardiomyopathy (AC; also referred to as ?ARVC? or ?ARVD?). Life-threatening ventricular arrhythmias often occur in the concealed phase of the disease before the onset of structural changes. Among the various potential mechanisms for arrhythmogenesis in AC, in this article we concentrate on the relation between desmosomes and sodium channel function. We review evidence indicating that: 1) loss of desmosomal integrity (including mutations or loss of expression of plakophilin-2; PKP2) leads to reduced sodium current (INa). 2) The PKP2-INa relation could be partly consequent to the fact that PKP2 facilitates proper trafficking of proteins to the intercalated disc 3) PKP2 mutations can be present in patients diagnosed with Brugada syndrome (BrS), thus supporting the previously-proposed notion that AC and BrS are not two completely separate entities, but ?bookends? in a continuum of variable sodium current deficiency and structural disease. Twit Text FOAVip Desmosomes and the sodium channel complex: implications for Arrhythmogenic Cardiomyopathy and Brugada Syndrome ????Trends Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=24656989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24656989 #FOAvip English Wikipedia <ref>{{Cite pmid|24656989}}</ref> Desmosomes and the sodium channel complex: implications for Arrhythmogenic Cardiomyopathy and Brugada Syndrome #MMPMID24656989 Cerrone M; Delmar M Trends Cardiovasc Med 2014[Jul]; 24 (5): 184-90 PMID24656989show ga Mutations in proteins of the desmosome associate with arrhythmogenic cardiomyopathy (AC; also referred to as ?ARVC? or ?ARVD?). Life-threatening ventricular arrhythmias often occur in the concealed phase of the disease before the onset of structural changes. Among the various potential mechanisms for arrhythmogenesis in AC, in this article we concentrate on the relation between desmosomes and sodium channel function. We review evidence indicating that: 1) loss of desmosomal integrity (including mutations or loss of expression of plakophilin-2; PKP2) leads to reduced sodium current (INa). 2) The PKP2-INa relation could be partly consequent to the fact that PKP2 facilitates proper trafficking of proteins to the intercalated disc 3) PKP2 mutations can be present in patients diagnosed with Brugada syndrome (BrS), thus supporting the previously-proposed notion that AC and BrS are not two completely separate entities, but ?bookends? in a continuum of variable sodium current deficiency and structural disease. äDesmosomes and the sodium channel complex: implications for Arrhythmog(epmc).pdf DeepDyve Pubget Overpricing