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10.1016/j.tim.2014.04.003

http://scihub22266oqcxt.onion/10.1016/j.tim.2014.04.003
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C4098856!4098856!24814671
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suck abstract from ncbi


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pmid24814671      Trends+Microbiol 2014 ; 22 (7): 406-16
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  • Clostridium difficile spore biology: sporulation, germination, and spore structural proteins #MMPMID24814671
  • Paredes-Sabja D; Shen A; Sorg JA
  • Trends Microbiol 2014[Jul]; 22 (7): 406-16 PMID24814671show ga
  • Clostridium difficile is a Gram-positive, spore-forming obligate anaerobe and a major nosocomial pathogen of world-wide concern. Due to its strict anaerobic requirements, the infectious and transmissible morphotype is the dormant spore. In susceptible patients, C. difficile spores germinate in the colon to form the vegetative cells that initiate Clostridium difficile infections (CDI). During CDI, C. difficile induces a sporulation pathway that produces more spores; these spores are responsible for the persistence of C. difficile in patients and horizontal transmission between hospitalized patients. While important to the C. difficile lifecycle, the C. difficile spore proteome is poorly conserved when compared to members of the Bacillus genus. Further, recent studies have revealed significant differences between C. difficile and B. subtilis at the level of sporulation, germination and spore coat and exosporium morphogenesis. In this review, the regulation of the sporulation and germination pathways and the morphogenesis of the spore coat and exosporium will be discussed.
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