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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Respir+Crit+Care+Med
2014 ; 189
(11
): 1309-15
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The upper respiratory tract as a microbial source for pulmonary infections in
cystic fibrosis Parallels from island biogeography
#MMPMID24702670
Whiteson KL
; Bailey B
; Bergkessel M
; Conrad D
; Delhaes L
; Felts B
; Harris JK
; Hunter R
; Lim YW
; Maughan H
; Quinn R
; Salamon P
; Sullivan J
; Wagner BD
; Rainey PB
Am J Respir Crit Care Med
2014[Jun]; 189
(11
): 1309-15
PMID24702670
show ga
A continuously mixed series of microbial communities inhabits various points of
the respiratory tract, with community composition determined by distance from
colonization sources, colonization rates, and extinction rates. Ecology and
evolution theory developed in the context of biogeography is relevant to clinical
microbiology and could reframe the interpretation of recent studies comparing
communities from lung explant samples, sputum samples, and oropharyngeal swabs.
We propose an island biogeography model of the microbial communities inhabiting
different niches in human airways. Island biogeography as applied to communities
separated by time and space is a useful parallel for exploring microbial
colonization of healthy and diseased lungs, with the potential to inform our
understanding of microbial community dynamics and the relevance of microbes
detected in different sample types. In this perspective, we focus on the
intermixed microbial communities inhabiting different regions of the airways of
patients with cystic fibrosis.