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10.1161/CIRCRESAHA.113.301141

http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.113.301141
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C4097142!4097142!24951765
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suck abstract from ncbi


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pmid24951765      Circ+Res 2014 ; 115 (1): 165-75
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  • Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension #MMPMID24951765
  • Rabinovitch M; Guignabert C; Humbert M; Nicolls MR
  • Circ Res 2014[Jun]; 115 (1): 165-75 PMID24951765show ga
  • This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated immunity in animal models of the disease are reviewed. In addition we present therapies that target inflammatory/immune mechanisms that are currently enrolling patients and discuss others in development. We show how genetic and metabolic abnormalities are inextricably linked to dysregulated immunity and adverse remodeling in the pulmonary arteries.
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